Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota
TLDR
Some of the health-related benefits of omega-3 may be due, in part, to increases in butyrate-producing bacteria, which may shed light on the mechanisms explaining the effects of Omega-3 in several chronic diseases and may also serve as an existing foundation for tailoring personalized medical treatments.Abstract:
Background. Recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. Among exogenous factors affecting gut microbiome, diet appears to have the largest effect. Fatty acids, especially omega-3 polyunsaturated, ameliorate a range of several diseases, including cardiometabolic and inflammatory and cancer. Fatty acids associated beneficial effects may be mediated, to an important extent, through changes in gut microbiota composition. We sought to understand the changes of the gut microbiota in response to an omega-3 rich diet. Case Presentation. This case study investigated changes of gut microbiota with an omega-3 rich diet. Fecal samples were collected from a 45-year-old male who consumed 600 mg of omega-3 daily for 14 days. After the intervention, species diversity was decreased, but several butyrate-producing bacteria increased. There was an important decrease in Faecalibacterium prausnitzii and Akkermansia spp. Gut microbiota changes were reverted after the 14-day washout. Conclusion. Some of the health-related benefits of omega-3 may be due, in part, to increases in butyrate-producing bacteria. These findings may shed light on the mechanisms explaining the effects of omega-3 in several chronic diseases and may also serve as an existing foundation for tailoring personalized medical treatments.read more
Citations
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The Controversial Role of Human Gut Lachnospiraceae.
Mirco Vacca,Giuseppe Celano,Francesco Maria Calabrese,Piero Portincasa,Marco Gobbetti,Maria De Angelis +5 more
TL;DR: Changes in Lachnospiraceae abundances according to health and disease are discussed and how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology are analyzed.
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Impact of Omega-3 Fatty Acids on the Gut Microbiota
TL;DR: Accumulating evidence in animal model studies indicates that the interplay between gut microbiota, omega-3 fatty acids, and immunity helps to maintain the intestinal wall integrity and interacts with host immune cells, encouraging further studies.
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Blautia-a new functional genus with potential probiotic properties?
Xuemei Liu,Mao Bingyong,Jiayu Gu,Jiaying Wu,Cui Shumao,Wang Gang,Jianxin Zhao,Hao Zhang,Wei Chen +8 more
TL;DR: Blautia is a genus of anaerobic bacteria with probiotic characteristics that occur widely in the feces and intestines of mammals as discussed by the authors based on phenotypic and phylogenetic analyses.
Journal ArticleDOI
Food Components and Dietary Habits: Keys for a Healthy Gut Microbiota Composition.
Emanuele Rinninella,Marco Cintoni,Pauline Raoul,Loris Riccardo Lopetuso,Franco Scaldaferri,Gabriele Pulcini,Giacinto Abele Donato Miggiano,Antonio Gasbarrini,Maria Cristina Mele +8 more
TL;DR: The present review aimed to focus on the impact of single food components, salt, food additives, and different dietary habits (i.e., vegan and vegetarian, gluten-free, ketogenic, high sugar, low FODMAP, Western-type, and Mediterranean diets) on gut microbiota composition in order to define the optimal diet for a healthy modulation of gut microbiota.
Journal ArticleDOI
A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota
Henry Watson,Suparna Mitra,Fiona Croden,M Taylor,Henry M. Wood,SL Perry,Jade A. Spencer,Phil Quirke,Giles J. Toogood,Clare L. Lawton,Louise Dye,Paul M. Loadman,Mark A. Hull +12 more
TL;DR: Omega-3 PUFA supplementation induces a reversible increase in several short-chain fatty acid-producing bacteria, independently of the method of administration, as well as a reversible increased abundance of several genera, including Bifidobacterium and Lactobacillus.
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