Journal ArticleDOI
Wound-healing properties of copper nanoparticles as a function of physicochemical parameters
A. A. Rakhmetova,T. P. Alekseeva,O. A. Bogoslovskaya,I. O. Leipunskii,I. P. Olkhovskaya,A. N. Zhigach,N. N. Glushchenko +6 more
TLDR
In this article, the wound-healing potential and physicochemical characteristics of copper nanoparticles prepared by high-temperature condensation and modified with a variety of agents (including oxygen, water vapors, and air) are reported.Abstract:
Results of a study on the wound-healing potential and physicochemical characteristics of copper nanoparticles prepared by high-temperature condensation and modified with a variety of agents (including oxygen, water vapors, and air) are reported. The modification of copper nanoparticles under monitored conditions guarantees the synthesis of particle species differing in size, phase composition, thickness, and composition of the oxide layer. Modified copper nanoparticles in the form of an ointment showed wound-healing behavior that differs in effectiveness depending on their physicochemical parameters. Nanoparticles of copper oxide (sample 7) (modified with air), with a particle size of 119 nm and crystalline copper content of ∼0.5%, and copper nanoparticles (sample 2) (modified with oxygen), with a particle size of 103 nm and crystalline copper content of 96%, demonstrated the maximum specific rate of wound adhesion.read more
Citations
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Mechanism of antibacterial activity of copper nanoparticles.
TL;DR: The results demonstrate that NP-mediated dissipation of cell membrane potential was the probable reason for the formation of cell filaments and proposes that the nascent Cu ions liberated from the NP surface were responsible for higher reactivity of the Cu-NPs than the equivalent amount of its precursor CuCl2.
Journal ArticleDOI
Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing.
Subhamoy Das,Aaron B. Baker +1 more
TL;DR: Recent advances in the development of biomaterials and nanoparticle therapeutics to enhance wound healing are discussed, focusing on the novel cutaneous wound treatments that have undergone significant preclinical development or are currently used in clinical practice.
Journal ArticleDOI
Chitosan Based Metallic Nanocomposite Scaffolds as Antimicrobial Wound Dressings
TL;DR: This review focuses on the different combinations of Chitosan metal nanocomposite scaffolds towards enhancement of healing or infection control with special reference to the antimicrobial mechanism of action and toxicity.
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Chitosan-based copper nanocomposite accelerates healing in excision wound model in rats.
TL;DR: It is concluded that chitosan-based copper nanocomposite efficiently enhanced cutaneous wound healing by modulation of various cells, cytokines and growth factors during different phases of healing process.
Journal ArticleDOI
Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles.
TL;DR: In this paper, the effects of surface chemistry such as ligand type and surface oxidation on the reactive oxygen species (ROS) generated by the copper nanoparticles were examined, and it was found that the nanoparticles with longer chain ligands had better protected surfaces from oxidation and a corresponding lower ROS generating capacity than did particles with shorter-chain ligands.
References
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Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
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Impact of heat on nanocrystalline silver dressings. Part I: Chemical and biological properties.
TL;DR: It was determined that the quantity of soluble silver decreased significantly with increased heat treatment temperatures, and should be considered in developing new nanocrystalline drug delivery systems.
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Sequential changes in trace metal, metallothionein and calmodulin concentrations in healing skin wounds.
TL;DR: Increases in metallothionein immunoreactivity are demonstrated as an indication of zinc and copper activity in the papillary dermis and in basal epidermal cells near the wound margin 1–5 d after wounding, consistent with metalloenzyme requirements in inflammation and fibrogenesis.