Topic
Opioid-Related Disorders
About: Opioid-Related Disorders is a research topic. Over the lifetime, 251 publications have been published within this topic receiving 10774 citations.
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TL;DR: A narrative review briefly describes the neurobiology of opioids and focuses on the complex issues at this interface between analgesia and abuse, including terminology, clinical challenges, and the potential for new agents, such as buprenorphine, to influence practice.
Abstract: Opioids have been regarded for millennia as among the most effective drugs for the treatment of pain. Their use in the management of acute severe pain and chronic pain related to advanced medical illness is considered the standard of care in most of the world. In contrast, the long-term administration of an opioid for the treatment of chronic noncancer pain continues to be controversial. Concerns related to effectiveness, safety, and abuse liability have evolved over decades, sometimes driving a more restrictive perspective and sometimes leading to a greater willingness to endorse this treatment. The past several decades in the United States have been characterized by attitudes that have shifted repeatedly in response to clinical and epidemiological observations, and events in the legal and regulatory communities. The interface between the legitimate medical use of opioids to provide analgesia and the phenomena associated with abuse and addiction continues to challenge the clinical community, leading to uncertainty about the appropriate role of these drugs in the treatment of pain. This narrative review briefly describes the neurobiology of opioids and then focuses on the complex issues at this interface between analgesia and abuse, including terminology, clinical challenges, and the potential for new agents, such as buprenorphine, to influence practice.
551 citations
TL;DR: Patients with CNCP prescribed opioids had significantly higher rates of OUDs compared with those not prescribed opioids, and duration of opioid therapy was more important than daily dose in determining OUD risk.
Abstract: Objective
Increasing rates of opioid use disorders (abuse and dependence) among patients prescribed opioids are a significant public health concern. We investigated the association between exposure to prescription opioids and incident opioid use disorders (OUDs) among individuals with a new episode of a chronic non-cancer pain (CNCP) condition.
401 citations
TL;DR: A general approach to identifying and treating opioid-use disorders is outlined.
Abstract: Opioid-use disorders are common, but most physicians are not trained to recognize and treat them. This review outlines a general approach to identifying and treating these disorders.
376 citations
22 Jun 2016
TL;DR: A new CDC guideline on prescribing opioids for chronic pain has only added to the media attention being focused on opioid abuse and addiction, but what does the guideline really offer?
Abstract: A new CDC guideline on prescribing opioids for chronic pain has only added to the media attention being focused on opioid abuse and addiction. But what does the guideline really offer?
291 citations