A
Afshan McCarthy
Researcher at Institute of Cancer Research
Publications - 31
Citations - 3868
Afshan McCarthy is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Gene & DNA repair. The author has an hindex of 24, co-authored 28 publications receiving 3515 citations. Previous affiliations of Afshan McCarthy include The Breast Cancer Research Foundation.
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Journal ArticleDOI
BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells
Gemma Molyneux,Felipe C. Geyer,Fiona-Ann Magnay,Afshan McCarthy,Howard Kendrick,Rachael Natrajan,Alan Mackay,Anita Grigoriadis,Andrew Tutt,Alan Ashworth,Jorge S. Reis-Filho,Matthew J. Smalley +11 more
TL;DR: It is demonstrated that deleting Brca1 in mouse mammary epithelial luminal progenitors produces tumors that phenocopy human BRCA1 breast cancers and that when target cells for transformation have the potential for phenotypic plasticity, tumor phenotypes may not directly reflect histogenesis.
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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
Ana M. Mendes-Pereira,Sarah A. Martin,Rachel Brough,Afshan McCarthy,Jessica R. Taylor,Jung-Sik Kim,Todd Waldman,Christopher J. Lord,Alan Ashworth +8 more
TL;DR: The data presented here now suggests that the clinical assessment of PARP inhibitors should be extended beyond those with BRCA mutations to a larger group of patients with PTEN mutant tumours.
Journal ArticleDOI
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Kei Sakamoto,Afshan McCarthy,Darrin P. Smith,Kevin A. Green,D. Grahame Hardie,Alan Ashworth,Dario R. Alessi +6 more
TL;DR: These studies establish the importance of LKB1 in regulating AMPK activity and cellular energy levels in response to contraction and phenformin and reduce phosphorylation and activation of AMPKα2.
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A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.
Monika Karla Graeser,Afshan McCarthy,Christopher J. Lord,Kay Savage,Margaret Hills,Janine Salter,Nick Orr,Marina Parton,Ian E. Smith,Jorge S. Reis-Filho,Mitchell Dowsett,Alan Ashworth,Nicholas C. Turner +12 more
TL;DR: The results suggest that defective HR, as indicated by low RAD51 score, may be one of the factors that underlie sensitivity to anthracycline-based chemotherapy.
Journal ArticleDOI
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes
Zheng Yin,Amine Sadok,Heba Z. Sailem,Afshan McCarthy,Xiaofeng Xia,Fuhai Li,Mar Arias Garcia,Louise Evans,Alexis R. Barr,Norbert Perrimon,Christopher J. Marshall,Stephen T. C. Wong,Chris Bakal +12 more
TL;DR: It is found that most genes regulate the transition between discrete shapes rather than generating new morphologies, and a subset of genes are identified that decrease the heterogeneity of the population, leading to populations enriched in rounded or elongated forms.