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Ana M. Mendes-Pereira
Researcher at Institute of Cancer Research
Publications - 11
Citations - 1359
Ana M. Mendes-Pereira is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: PTEN & Tensin. The author has an hindex of 7, co-authored 9 publications receiving 1262 citations. Previous affiliations of Ana M. Mendes-Pereira include The Breast Cancer Research Foundation.
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Journal ArticleDOI
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
Ana M. Mendes-Pereira,Sarah A. Martin,Rachel Brough,Afshan McCarthy,Jessica R. Taylor,Jung-Sik Kim,Todd Waldman,Christopher J. Lord,Alan Ashworth +8 more
TL;DR: The data presented here now suggests that the clinical assessment of PARP inhibitors should be extended beyond those with BRCA mutations to a larger group of patients with PTEN mutant tumours.
Journal ArticleDOI
PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors
Konstantin J. Dedes,Daniel Wetterskog,Ana M. Mendes-Pereira,Rachael Natrajan,Maryou B K Lambros,Felipe C. Geyer,Radost Vatcheva,Kay Savage,Alan Mackay,Christopher J. Lord,Alan Ashworth,Jorge S. Reis-Filho +11 more
TL;DR: The authors demonstrate that endometrial cancer cell lines that lack the tumor suppressor protein PTEN show defects in the repair of DNA damage and are consequently very sensitive to drugs that block poly(ADP) ribose polymerase (PARP), an enzyme critical for DNA repair.
Journal ArticleDOI
Functional viability profiles of breast cancer
Rachel Brough,Jessica Frankum,David Sims,Alan Mackay,Ana M. Mendes-Pereira,Ilirjana Bajrami,Sara Costa-Cabral,Rumana Rafiq,Amar Ahmad,Maria Antonietta Cerone,Rachael Natrajan,Rachel Sharpe,Kai-Keen Shiu,Daniel Wetterskog,Konstantine J. Dedes,Maryou B. Lambros,Teeara Rawjee,Spiros Linardopoulos,Jorge S. Reis-Filho,Nicholas C. Turner,Christopher J. Lord,Alan Ashworth +21 more
TL;DR: A functional genetic screen in >30 commonly used models of breast cancer to identify genes critical to the growth of specific breast cancer subtypes is carried out and potential new therapeutic targets for PTEN-mutated cancers and for estrogen receptor-positive breast cancers are described.
Journal ArticleDOI
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing
David Sims,Ana M. Mendes-Pereira,Jessica Frankum,Darren J. Burgess,Maria Antonietta Cerone,Cristina Lombardelli,Costas Mitsopoulos,Jarle Hakas,Nirupa Murugaesu,Clare M. Isacke,Kerry Fenwick,Ioannis Assiotis,Iwanka Kozarewa,Marketa Zvelebil,Alan Ashworth,Christopher J. Lord +15 more
TL;DR: This work describes complete experimental protocols and novel open source computational methodologies, shALIGN and shRNAseq, that allow RNAi screens to be rapidly deconvoluted using next generation sequencing.
Journal ArticleDOI
Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
Ana M. Mendes-Pereira,David Sims,Tim Dexter,Kerry Fenwick,Ioannis Assiotis,Iwanka Kozarewa,Costas Mitsopoulos,Jarle Hakas,Marketa Zvelebil,Christopher J. Lord,Alan Ashworth +10 more
TL;DR: Combining whole-genome shRNA screening with massively parallel sequencing, this work has profiled the impact of more than 56,670 RNA interference reagents targeting 16,487 genes on the cellular response to tamoxifen.