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Alain Destexhe
Researcher at Centre national de la recherche scientifique
Publications - 375
Citations - 23667
Alain Destexhe is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Local field potential & Inhibitory postsynaptic potential. The author has an hindex of 73, co-authored 342 publications receiving 21506 citations. Previous affiliations of Alain Destexhe include Laval University & European Institute.
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The high-conductance state of neocortical neurons in vivo.
TL;DR: Results from different approaches in understanding the integrative properties of neocortical neurons in the intact brain are summarized to help understand the complex interplay between the active properties of dendrites and how they convey discrete synaptic inputs to the soma.
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Simulation of networks of spiking neurons: A review of tools and strategies
Romain Brette,Michelle Rudolph,Ted Carnevale,Michael L. Hines,David Beeman,James M. Bower,Markus Diesmann,Markus Diesmann,Abigail Morrison,Philip H. Goodman,Frederick C. Harris,Milind Zirpe,Thomas Natschläger,Dejan Pecevski,G. Bard Ermentrout,Mikael Djurfeldt,Anders Lansner,Olivier Rochel,Thierry Viéville,Eilif Muller,Andrew P. Davison,Sami El Boustani,Alain Destexhe +22 more
TL;DR: In this paper, a review of different aspects of the simulation of spiking neural networks is presented, with the aim of identifying the appropriate integration strategy and simulation tool to use for a given modeling problem related to spiking networks.
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Low-dimensional chaos in an instance of epilepsy.
TL;DR: Using a time series obtained from the electroencephalogram recording of a human epileptic seizure, the existence of a chaotic attractor is shown, the latter being the direct consequence of the deterministic nature of brain activity.
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Impact of Network Activity on the Integrative Properties of Neocortical Pyramidal Neurons In Vivo
Alain Destexhe,Denis Paré +1 more
TL;DR: In this article, the authors studied the impact of network activity on the integrative properties of pyramidal neurons in vivo and found that during wakefulness, neurons are subjected to an intense synaptic bombardment.
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Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons.
Alain Destexhe,Michael Rudolph,Jean Marc Fellous,Terrence J. Sejnowski,Terrence J. Sejnowski +4 more
TL;DR: Many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically, including a depolarized membrane potential and the presence of high-amplitude membrane potential fluctuations.