Alan S. Waggoner

TL;DR: Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo, using only quantum dots for detection.

TL;DR: A series of new fluorescent labeling reagents based on sulfoindocyanine dyes contain succinimidyl ester reactive groups and can be readily conjugated to antibodies, avidin, DNA, lipids, polymers, and other amino-group-containing materials.

TL;DR: The development of protein reporters that generate fluorescence from otherwise dark molecules (fluorogens) is reported, isolated by screening a library of human single-chain antibodies using derivatives of thiazole orange and malachite green.

TL;DR: It is demonstrated that quantum dots injected into two model tumors rapidly migrate to sentinel lymph nodes and Examination of the sentinel nodes identified by quantum dot localization showed that at least some contained metastatic tumor foci.

TL;DR: Ten carboxymethylindocyanine dyes which form the basis of a new series of fluorescent probes have been synthesized and converted into succinimidyl active esters for fluorescent labeling of proteins or other amino-containing substances and the use of values of chromophore-equivalent weight (W/Ceq), calculated from quantitative absorption data on dye samples, is proposed.