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Alexander Gottschalk
Researcher at Goethe University Frankfurt
Publications - 404
Citations - 25825
Alexander Gottschalk is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Pulmonary embolism & Optogenetics. The author has an hindex of 73, co-authored 397 publications receiving 24195 citations. Previous affiliations of Alexander Gottschalk include University of California, San Francisco & Argonne National Laboratory.
Papers
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Journal ArticleDOI
Multimodal fast optical interrogation of neural circuitry
Feng Zhang,Liping Wang,Martin Brauner,Jana F. Liewald,Kenneth Kay,Natalie Watzke,Phillip G. Wood,Ernst Bamberg,Ernst Bamberg,Georg Nagel,Alexander Gottschalk,Karl Deisseroth +11 more
TL;DR: An archaeal light-driven chloride pump from Natronomonas pharaonis is identified and developed for temporally precise optical inhibition of neural activity and forms a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits.
Journal Article
Multimodal fast optical interrogation of neural circuitry
Feng Zhang,Liping Wang,Martin Brauner,Jana F. Liewald,Kenneth Kay,Natalie Watzke,Phillip G. Wood,Ernst Bamberg,Georg Nagel,Alexander Gottschalk,Karl Deisseroth +10 more
TL;DR: In this paper, an archaeal light-driven chloride pump (NpHR) was developed for temporally precise optical inhibition of neural activity, allowing either knockout of single action potentials, or sustained blockade of spiking.
Journal ArticleDOI
Multidetector Computed Tomography for Acute Pulmonary Embolism
Paul D. Stein,Sarah E. Fowler,Lawrence R. Goodman,Alexander Gottschalk,Charles A. Hales,Russell D. Hull,Kenneth V. Leeper,John Popovich,Deborah A. Quinn,Thomas A. Sos,H. Dirk Sostman,Victor F. Tapson,Thomas W. Wakefield,John G. Weg,Pamela K. Woodard +14 more
TL;DR: In patients with suspected pulmonary embolism, multidetector CTA-CTV has a higher diagnostic sensitivity than does CTA alone, with similar specificity, and additional testing is necessary when the clinical probability is inconsistent with the imaging results.
Journal ArticleDOI
Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses
Georg Nagel,Martin Brauner,Jana F. Liewald,Nona Adeishvili,Ernst Bamberg,Alexander Gottschalk +5 more
TL;DR: Channelrhodopsin-2 (ChR2) is employed, a directly light-gated cation channel from the green alga Chlamydomonas reinhardtii, in excitable cells of the nematode Caenorhabditis elegans, to trigger specific behaviors, simply by illumination, in neurons and muscles.
Journal ArticleDOI
Loss of PTEN facilitates HIF-1-mediated gene expression
Wayne Zundel,Cornelia Schindler,Daphne A. Haas-Kogan,Albert C. Koong,Fiona Kaper,Eunice Y. Chen,Alexander Gottschalk,Heather E. Ryan,Randall S. Johnson,Anne B. Jefferson,David Stokoe,Amato J. Giaccia +11 more
TL;DR: It is proposed that loss of PTEN during malignant progression contributes to tumor expansion through the deregulation of Akt activity and HIF-1-regulated gene expression.