A
Almudena Ortega-Gomez
Researcher at Ludwig Maximilian University of Munich
Publications - 35
Citations - 2536
Almudena Ortega-Gomez is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Inflammation & Medicine. The author has an hindex of 19, co-authored 30 publications receiving 1800 citations. Previous affiliations of Almudena Ortega-Gomez include French Institute of Health and Medical Research & Spanish National Research Council.
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Journal ArticleDOI
Resolution of inflammation: an integrated view
TL;DR: This review integrates the key molecular and cellular mechanisms of resolution and describes how abrogation of chemokine signalling blocks continued neutrophil tissue infiltration and how apoptotic neutrophils attract monocytes and macrophages to induce their clearance.
Journal ArticleDOI
Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis
Karin C. A. A. Wildhagen,Pablo García de Frutos,Chris P. M. Reutelingsperger,Roy Schrijver,Cristina Aresté,Almudena Ortega-Gomez,Niko Deckers,H. Coenraad Hemker,Oliver Soehnlein,Oliver Soehnlein,Gerry A. F. Nicolaes +10 more
TL;DR: It is shown that nonanticoagulant heparin, purified from clinical grade heparIn, binds histones and prevents histone-mediated cytotoxicity in vitro and reduces mortality from sterile inflammation and sepsis in mouse models without increasing the risk of bleeding.
Journal ArticleDOI
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
Carlos Silvestre-Roig,Quinte Braster,Kanin Wichapong,Ernest Y. Lee,Jean Marie Teulon,Nihel Berrebeh,Janine Winter,José M. Adrover,Giancarlo Santiago Santos,Alexander Froese,Patricia Lemnitzer,Almudena Ortega-Gomez,Raphael Chevre,Julian A. Marschner,Ariane Schumski,Carla Winter,Laura Perez-Olivares,Chang Pan,Nicole Paulin,Tom Schoufour,Helene Hartwig,Silvia González-Ramos,Frits Kamp,Remco T. A. Megens,Kerri A. Mowen,Matthias Gunzer,Lars Maegdefessel,Lars Maegdefessel,Tilman M. Hackeng,Esther Lutgens,Mat J.A.P. Daemen,Julia von Blume,Hans-Joachim Anders,Viacheslav O. Nikolaev,Jean-Luc Pellequer,Christian Weber,Christian Weber,Andrés Hidalgo,Andrés Hidalgo,Gerry A. F. Nicolaes,Gerard C. L. Wong,Oliver Soehnlein +41 more
TL;DR: This work demonstrates that extracellular histone H4-mediated membrane lysis of smooth muscle cells (SMCs) triggers arterial tissue damage and inflammation, and identifies a form of cell death found at the core of chronic vascular disease that is instigated by leukocytes and can be targeted therapeutically.
Journal ArticleDOI
Neutrophils as regulators of cardiovascular inflammation.
Carlos Silvestre-Roig,Quinte Braster,Almudena Ortega-Gomez,Oliver Soehnlein,Oliver Soehnlein +4 more
TL;DR: The influence of traditional and novel cardiovascular risk factors on neutrophil production and function is discussed and the current knowledge of the contribution of neutrophils to the different stages of atherosclerosis, including atherogenesis, plaque destabilization and plaque erosion is appraised.
Journal ArticleDOI
Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes
Oliver Soehnlein,Oliver Soehnlein,Oliver Soehnlein,Maik Drechsler,Maik Drechsler,Yvonne Döring,Yvonne Döring,Dirk Lievens,Dirk Lievens,Helene Hartwig,Klaus Kemmerich,Almudena Ortega-Gomez,Manuela Mandl,Santosh Vijayan,Delia Projahn,Christoph D. Garlichs,Robert Ryan Koenen,Robert Ryan Koenen,Mihail Hristov,Esther Lutgens,Esther Lutgens,Alma Zernecke,Alma Zernecke,Christian Weber +23 more
TL;DR: The impact of classical monocytes on atheroprogression is established, a sequential role of CXCL1 in their mobilization and CCR1/CCR5 in their recruitment is identified and a preferential role for the CX CL1/CXCR2 axis is indicated in mobilizing classicalmonocytes during hypercholesterolemia.