A
Andrew R. Joyce
Researcher at University of California, San Diego
Publications - 25
Citations - 4567
Andrew R. Joyce is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Gene & Metabolic network. The author has an hindex of 20, co-authored 25 publications receiving 4351 citations. Previous affiliations of Andrew R. Joyce include University of San Diego & Emory University.
Papers
More filters
Journal ArticleDOI
A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information.
Adam M. Feist,Christopher S. Henry,Jennifer L. Reed,Markus Krummenacker,Andrew R. Joyce,Peter D. Karp,Linda J. Broadbelt,Vassily Hatzimanikatis,Bernhard O. Palsson +8 more
TL;DR: An updated genome‐scale reconstruction of the metabolic network in Escherichia coli K‐12 MG1655 with increased scope and computational capability is presented, expected to broaden the spectrum of both basic biology and applied systems biology studies of E. coli metabolism.
Journal ArticleDOI
The model organism as a system: integrating 'omics' data sets.
TL;DR: Researchers are rising to the challenge by using omics data integration to address fundamental biological questions that would increase the understanding of systems as a whole.
Journal ArticleDOI
Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale.
Christopher D. Herring,Christopher D. Herring,Christopher D. Herring,Anu Raghunathan,Anu Raghunathan,Anu Raghunathan,Christiane Honisch,Trina R. Patel,M. Kenyon Applebee,Andrew R. Joyce,Thomas J. Albert,Frederick R. Blattner,Dirk van den Boom,Charles R. Cantor,Bernhard O. Palsson +14 more
TL;DR: This article applied whole-genome resequencing of Escherichia coli to monitor the acquisition and fixation of mutations that conveyed a selective growth advantage during adaptation to a glycerol-based growth medium.
Journal ArticleDOI
Parallel adaptive evolution cultures of Escherichia coli lead to convergent growth phenotypes with different gene expression states
TL;DR: The results from parallel, replicate adaptive evolution experiments of Escherichia coli K-12 MG1655 grown on either lactate or glycerol minimal media showed that growth phenotypes at the endpoint of evolution are convergent and reproducible.
Journal ArticleDOI
Systems approach to refining genome annotation.
Jennifer L. Reed,Trina R. Patel,Keri H. Chen,Andrew R. Joyce,Margaret K. Applebee,Christopher D. Herring,Olivia T. Bui,Eric M. Knight,Stephen S. Fong,Bernhard O. Palsson +9 more
TL;DR: An optimization-based algorithm is introduced that predicts the missing reactions that are required to reconcile computation and experiment when they disagree and is demonstrated by a combination of experimental and computational approaches.