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Anthony P. Hollander
Researcher at University of Liverpool
Publications - 97
Citations - 10811
Anthony P. Hollander is an academic researcher from University of Liverpool. The author has contributed to research in topics: Cartilage & Type II collagen. The author has an hindex of 48, co-authored 95 publications receiving 10270 citations. Previous affiliations of Anthony P. Hollander include University of Bristol & University of Sheffield.
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Journal ArticleDOI
Clinical transplantation of a tissue-engineered airway
Paolo Macchiarini,Philipp Jungebluth,Tetsuhiko Go,M. Adelaide Asnaghi,Louisa E.N. Rees,Tristan A Cogan,A. Dodson,Jaume Martorell,Silvia Bellini,Pier Paolo Parnigotto,Sally C. Dickinson,Anthony P. Hollander,Sara Mantero,Maria Teresa Conconi,Martin A. Birchall +14 more
TL;DR: The results show that a cellular, tissue-engineered airway with mechanical properties that allow normal functioning, and which is free from the risks of rejection, is produced, suggesting that autologous cells combined with appropriate biomaterials might provide successful treatment for patients with serious clinical disorders.
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The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration.
John Antoniou,Thomas Steffen,Fred Nelson,Neil Winterbottom,Anthony P. Hollander,Robin A. Poole,Max Aebi,Mauro Alini +7 more
TL;DR: Three matrix turnover phases are identified and evidence is illustrated for a lack of increased synthesis of aggrecan and type II procollagen, but also by an increase in collagen type II denaturation and type I Procollagen synthesis, both dependent on age and grade of tissue degeneration.
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Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.
TL;DR: The epitope recognized by the antibody was resistant to cleavage by alpha-chymotrypsin and proteinase K which were used to extract alpha 1 (II)-CB11B from the denatured and residual native collagen alpha-chains present in human femoral articular cartilage.
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Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS).
Pierre Mainil-Varlet,Thomas Aigner,Mats Brittberg,Peter Bullough,Anthony P. Hollander,Ernst B. Hunziker,Rita A. Kandel,Stefan Nehrer,Kenneth P.H. Pritzker,Sally Roberts,Edouard Stauffer +10 more
TL;DR: Articular cartilage is a narrow layer of specialized connective tissue that permits smooth, frictionless movement of diarthrodial joints that is distinguished by the shape of the chondrocytes and the arrangement of type-II collagen fibers.
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Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.
TL;DR: In both aging and OA the first damage to type II collagen occurs in the superficial and upper mid zone (low MG) extending to the lower mid and deep zones with increasing degeneration (increasing MG), and initial damage is always seen around chondrocytes implicating them in the denaturation oftype II collagen.