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Bart Loeys
Researcher at University of Antwerp
Publications - 300
Citations - 23857
Bart Loeys is an academic researcher from University of Antwerp. The author has contributed to research in topics: Marfan syndrome & Medicine. The author has an hindex of 67, co-authored 253 publications receiving 20831 citations. Previous affiliations of Bart Loeys include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
The revised Ghent nosology for the Marfan syndrome
Bart Loeys,Harry C. Dietz,Alan C. Braverman,Bert Callewaert,Julie De Backer,Richard B. Devereux,Yvonne Hilhorst-Hofstee,Guillaume Jondeau,Laurence Faivre,Dianna M. Milewicz,Reed E. Pyeritz,Paul D. Sponseller,Paul Wordsworth,Anne De Paepe +13 more
TL;DR: A revised Ghent nosology is established, which puts more weight on the cardiovascular manifestations and in which aortic root aneurysm and ectopia lentis are the cardinal clinical features and may delay a definitive diagnosis of MFS but will decrease the risk of premature or misdiagnosis.
Journal ArticleDOI
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Jennifer P Habashi,Daniel P. Judge,Tammy M. Holm,Ronald D. Cohn,Bart Loeys,Timothy K. Cooper,Loretha Myers,Erin C Klein,Guosheng Liu,Carla L. Calvi,Megan Podowski,Enid Neptune,Marc K. Halushka,Djahida Bedja,Kathleen L. Gabrielson,Daniel B. Rifkin,Luca Carta,Francesco Ramirez,David L. Huso,Harry C. Dietz +19 more
TL;DR: Losartan, a drug already in clinical use for hypertension, merits investigation as a therapeutic strategy for patients with Marfan syndrome and has the potential to prevent the major life-threatening manifestation of this disorder.
Journal ArticleDOI
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Bart Loeys,Junji Chen,Enid Neptune,Daniel P. Judge,Megan Podowski,Tammy M. Holm,Jennifer Meyers,Carmen C. Leitch,Nicholas Katsanis,Neda A. Sharifi,F Lauren Xu,Loretha Myers,Philip J. Spevak,Duke E. Cameron,Julie De Backer,Jan Hellemans,Yan Chen,Elaine C. Davis,Catherine L. Webb,Wolfram Kress,Paul Coucke,Daniel B. Rifkin,Anne De Paepe,Harry C. Dietz +23 more
TL;DR: These data definitively implicate perturbation of TGFβ signaling in many common human phenotypes, including craniosynostosis, cleft palate, arterial aneurysms, congenital heart disease and mental retardation, and suggest that comprehensive mechanistic insight will require consideration of both primary and compensatory events.
Journal ArticleDOI
Aneurysm Syndromes Caused by Mutations in the TGF-β Receptor
Bart Loeys,Bart Loeys,Ulrike Schwarze,Tammy M. Holm,Bert Callewaert,George H. Thomas,George H. Thomas,Hariyadarshi Pannu,Julie De Backer,Gretchen L. Oswald,Sofie Symoens,Sylvie Manouvrier,Amy E. Roberts,Francesca Faravelli,M. Alba Greco,Reed E. Pyeritz,Dianna M. Milewicz,Paul Coucke,Duke E. Cameron,Alan C. Braverman,Peter H. Byers,Anne De Paepe,Harry C. Dietz,Harry C. Dietz +23 more
TL;DR: An additional cohort of 40 patients who had vascular Ehlers–Danlos syndrome without the characteristic type III collagen abnormalities or the craniofacial features of the Loeys–Dietz syndrome were screened and a mutation in TGFBR1 or TGF BR2 was found.
Journal ArticleDOI
Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome
Benjamin S. Brooke,Jennifer P Habashi,Daniel P. Judge,Nishant D. Patel,Bart Loeys,Bart Loeys,Harry C. Dietz +6 more
TL;DR: In a small cohort study, the use of ARB therapy in patients with Marfan's syndrome significantly slowed the rate of progressive aortic-root dilation.