P
Paul D. Sponseller
Researcher at Johns Hopkins University
Publications - 568
Citations - 18278
Paul D. Sponseller is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Scoliosis & Medicine. The author has an hindex of 63, co-authored 487 publications receiving 15186 citations. Previous affiliations of Paul D. Sponseller include University of Wisconsin-Madison & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
The revised Ghent nosology for the Marfan syndrome
Bart Loeys,Harry C. Dietz,Alan C. Braverman,Bert Callewaert,Julie De Backer,Richard B. Devereux,Yvonne Hilhorst-Hofstee,Guillaume Jondeau,Laurence Faivre,Dianna M. Milewicz,Reed E. Pyeritz,Paul D. Sponseller,Paul Wordsworth,Anne De Paepe +13 more
TL;DR: A revised Ghent nosology is established, which puts more weight on the cardiovascular manifestations and in which aortic root aneurysm and ectopia lentis are the cardinal clinical features and may delay a definitive diagnosis of MFS but will decrease the risk of premature or misdiagnosis.
Journal ArticleDOI
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis
Gehua Zhen,Chunyi Wen,Chunyi Wen,Xiaofeng Jia,Yu Li,Janet L. Crane,Simon C. Mears,Frederic B. Askin,Frank J. Frassica,Weizhong Chang,Jie Yao,John A. Carrino,Andrew J. Cosgarea,Dmitri Artemov,Qianming Chen,Zhihe Zhao,Xuedong Zhou,Lee H. Riley,Paul D. Sponseller,Mei Wan,William W. Lu,William W. Lu,Xu Cao +22 more
TL;DR: It is shown that transforming growth factor β1 is activated in subchondral bone in response to altered mechanical loading in an anterior cruciate ligament transection mouse model of osteoarthritis, and inhibition of this process could be a potential therapeutic approach to treating this disease.
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Complications of growing-rod treatment for early-onset scoliosis: analysis of one hundred and forty patients
Shay Bess,Behrooz A. Akbarnia,George H. Thompson,Paul D. Sponseller,Suken A. Shah,Hazem El Sebaie,Oheneba Boachie-Adjei,Lawrence I. Karlin,Sarah Canale,Connie Poe-Kochert,David L. Skaggs +10 more
TL;DR: Complications can be reduced by delaying initial implantation of the growing rods if possible, using dual rods, and limiting the number of lengthening procedures.
Journal ArticleDOI
Loeys-Dietz syndrome: a primer for diagnosis and management
Gretchen MacCarrick,James H. Black,Sarah Bowdin,Ismail El-Hamamsy,Pamela A. Frischmeyer-Guerrerio,Anthony L. Guerrerio,Paul D. Sponseller,Bart Loeys,Harry C. Dietz +8 more
TL;DR: This review of literature and expert opinion aims to provide medical guidelines for care of individuals with Loeys–Dietz syndrome.
Journal ArticleDOI
Deep wound infections after neuromuscular scoliosis surgery: a multicenter study of risk factors and treatment outcomes.
Paul D. Sponseller,Dawn M. Laporte,Marc W. Hungerford,Kevin R. Eck,Keith H. Bridwell,Lawrence G. Lenke +5 more
TL;DR: Patients with cerebral palsy or myelomeningocele who have severe cognitive impairment, and those who received allograft may be at increased risk for infection, and infections are more often polymicrobial andcaused by gram-negative organisms than is typical for elective orthopedic procedures.