Bedair Dewidar

TL;DR: Light is shed on the state‐of‐the‐art in the signalling pathways induced by TGF‐β that are involved in different stages of liver physiology and pathology that are being explored to counteract liver disease progression.

TL;DR: Impact of TGF-β on liver fibrogenesis related biological processes, such as senescence, metabolism, reactive oxygen species generation, epigenetics, circadian rhythm, epithelial mesenchymal transition, and endothelial-mesenchyal transition are described.

TL;DR: The present review builds on knowledge of the last two decades about TGF-β function in myofibroblast generation and fibrogenesis, and presents the milestone discoveries from the recent 3–5 years, which include findings on downstream targets with fibrogenic function, pathways that facilitate T GF-β expression in HSC, and miRNAs regulated by or regulating the TDF-β pathway.

TL;DR: The bidirectional relationship between mechanisms underlying T2DM and NAFLD, the relevance of novel biomarkers for improving the diagnostic modalities and the identification of subgroups at specific risk of disease progression are addressed.

TL;DR: 24 highly expressed ERK gene signatures that their combined expression strongly indicates a dysregulated metabolic gene network in human HCC tissues are identified and offer novel insights for understanding, predicting and overcoming drug resistance in liver cancer patients.