Isabel Fabregat

TL;DR: It is shown that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals, indicating that with respect to oncogenesis, although a deregulation/ increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization.

TL;DR: Light is shed on the state‐of‐the‐art in the signalling pathways induced by TGF‐β that are involved in different stages of liver physiology and pathology that are being explored to counteract liver disease progression.

TL;DR: Results indicate that during the apoptosis mediated by TGF‐ß in fetal hepatocytes, ROS may be responsible for the decrease in bcl‐xL mRNA levels that precedes the loss of Δψm, the release of cytochrome c, and the activation of caspase 3, culminating in cell death.

TL;DR: Recent evidence indicates that inflammatory processes, as well as the epithelial-mesenchymal transitions that occur in HCC cells to facilitate their dissemination, are related to cell survival, and therapeutic strategies to selectively inhibit anti-apoptotic signals in liver tumor cells have the potential to provide powerful tools to treat HCC.

TL;DR: In this article, it was shown that TGF-β-induced apoptosis in fetal hepatocytes was preceded by an induction of reactive oxygen species production and a decrease in the glutathione intracellular content.