B
Benedikt Preckel
Researcher at University of Amsterdam
Publications - 225
Citations - 5798
Benedikt Preckel is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Perioperative & Ischemic preconditioning. The author has an hindex of 38, co-authored 206 publications receiving 4778 citations. Previous affiliations of Benedikt Preckel include Amsterdam University College & University of Düsseldorf.
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Journal ArticleDOI
The influence of mitochondrial KATP-channels in the cardioprotection of preconditioning and postconditioning by sevoflurane in the rat in vivo.
Detlef Obal,Saskia Dettwiler,Christian Favoccia,Horst Scharbatke,Benedikt Preckel,Wolfgang Schlack +5 more
TL;DR: The combination of preconditioning and postconditioning provides additive cardioprotection and is mediated, at least in part, by mKATP-channels.
Journal ArticleDOI
The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK.
Nina C. Weber,O. Toma,J. I. Wolter,Detlef Obal,Jost Müllenheim,Benedikt Preckel,Wolfgang Schlack +6 more
TL;DR: It is demonstrated that xenon induces cardioprotection by PC and that activation of PKC‐ɛ and its downstream target p38 MAPK are central molecular mechanisms involved.
Journal ArticleDOI
Molecular mechanisms transducing the anesthetic, analgesic, and organ protective actions of xenon
TL;DR: Clinical trials to assess the impact of xenon in settings with a high probability of injury such as cardiopulmonary bypass and neonatal asphyxia should be designed and underpinned with investigation of the molecular targets that transduce these effects.
Journal ArticleDOI
One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo
Detlef Obal,Benedikt Preckel,Horst Scharbatke,Jost Müllenheim,F. Höterkes,Volker Thämer,Wolfgang Schlack +6 more
TL;DR: This investigation investigated whether the cardioprotection induced by sevoflurane against myocardial reperfusion injury was concentration-dependent and found it to be so, as to protect the heart against reperfusions.
Journal ArticleDOI
Remote ischemic conditioning to protect against ischemia-reperfusion injury: a systematic review and meta-analysis.
Daniel Brevoord,Peter Kranke,Marijn Kuijpers,Nina C. Weber,Markus W. Hollmann,Benedikt Preckel +5 more
TL;DR: There is no evidence that remote ischemic conditioning reduces mortality associated with ischemia reperfusion events; nor does it reduce major adverse cardiovascular events; but it did reduce the incidence of peri-procedural myocardial infarctions, as well as the release of troponin.