B
Brent W. Zanke
Researcher at Cancer Care Ontario
Publications - 32
Citations - 2185
Brent W. Zanke is an academic researcher from Cancer Care Ontario. The author has contributed to research in topics: Colorectal cancer & Single-nucleotide polymorphism. The author has an hindex of 17, co-authored 32 publications receiving 1992 citations. Previous affiliations of Brent W. Zanke include Ottawa Hospital Research Institute & University of Ottawa.
Papers
More filters
Journal ArticleDOI
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
Brent W. Zanke,Celia M. T. Greenwood,Celia M. T. Greenwood,Jagadish Rangrej,Rafal Kustra,Rafal Kustra,Albert Tenesa,Susan M. Farrington,James G. D. Prendergast,Sylviane Olschwang,Theodore Chiang,Edgar Crowdy,Vincent Ferretti,Philippe Laflamme,Saravanan Sundararajan,Stéphanie Roumy,Jean François Olivier,Frederick Robidoux,Robert Sladek,Alexandre Montpetit,Peter T. Campbell,Stéphane Bézieau,Anne Marie O'Shea,George Zogopoulos,Michelle Cotterchio,Michelle Cotterchio,Polly A. Newcomb,John R. McLaughlin,John R. McLaughlin,Ban Younghusband,Roger C. Green,Jane Green,Mary Porteous,Harry Campbell,Hélène Blanché,Mourad Sahbatou,Emmanuel Tubacher,Catherine Bonaïti-Pellié,Bruno Buecher,Elio Riboli,Sébastien Küry,Stephen J. Chanock,John D. Potter,Gilles Thomas,Steven Gallinger,Steven Gallinger,Thomas J. Hudson,Thomas J. Hudson,Malcolm G. Dunlop +48 more
TL;DR: Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, markers in chromosomal region 8q24 associated with colorectal cancer were identified and this locus has been implicated in prostate cancer.
Journal ArticleDOI
Predictive models for breast cancer susceptibility from multiple single nucleotide polymorphisms.
Jennifer Listgarten,Sambasivarao Damaraju,B. Poulin,Lillian Cook,Jennifer Dufour,Adrian Driga,John R. Mackey,David S. Wishart,Russell Greiner,Brent W. Zanke +9 more
TL;DR: It is shown that multiple SNP sites from different genes over distant parts of the genome are better at identifying breast cancer patients than any one SNP alone.
Journal Article
Constitutive p38HOG Mitogen-activated Protein Kinase Activation Induces Permanent Cell Cycle Arrest and Senescence
Rizwan Haq,James D. Brenton,Mark Takahashi,Dina Finan,Ariel Finkielsztein,Sambasivarao Damaraju,Robert Rottapel,Brent W. Zanke +7 more
TL;DR: Stable expression of an activated form of MKK6 (MKK6EE), a direct activator of the stress-induced p38(HOG) mitogen-activated protein kinase pathway is sufficient for inducing features of senescence including a flattened, vacuolated, and irregular morphology, staining for acidic beta-galactosidase, and accumulation of age-associated pigments.
Journal ArticleDOI
Germ-line DNA copy number variation frequencies in a large North American population
George Zogopoulos,Kevin C.H. Ha,Faisal Naqib,Sara Moore,Hyeja Kim,Alexandre Montpetit,Frederick Robidoux,Philippe Laflamme,Michelle Cotterchio,Celia M. T. Greenwood,Stephen W. Scherer,Brent W. Zanke,Brent W. Zanke,Thomas J. Hudson,Thomas J. Hudson,Gary D. Bader,Gary D. Bader,Steven Gallinger,Steven Gallinger +18 more
TL;DR: A genomic map of 578 CNV regions was constructed, covering approximately 220 Mb (7.3%) of the human genome, identifying 183 previously unknown intervals, and will be a useful resource for future genetic studies.
Journal ArticleDOI
Are health care providers who work with cancer drugs at an increased risk for toxic events? A systematic review and meta-analysis of the literature.
G. Dranitsaris,Mary Johnston,Susan Poirier,T. Trudi Schueller,Debbie Milliken,Esther Green,Brent W. Zanke +6 more
TL;DR: A systematic review and meta-analysis conducted to test the hypothesis that oncology health care workers are at an increased risk of cancer, reproductive complications and acute toxic events identified a small incremental risk for spontaneous abortions in female staff working with cytotoxic agents.