Journal ArticleDOI
Are health care providers who work with cancer drugs at an increased risk for toxic events? A systematic review and meta-analysis of the literature.
G. Dranitsaris,Mary Johnston,Susan Poirier,T. Trudi Schueller,Debbie Milliken,Esther Green,Brent W. Zanke +6 more
TLDR
A systematic review and meta-analysis conducted to test the hypothesis that oncology health care workers are at an increased risk of cancer, reproductive complications and acute toxic events identified a small incremental risk for spontaneous abortions in female staff working with cytotoxic agents.Abstract:
Objective. A systematic review and meta-analysis was conducted to test the hypothesis that oncology health care workers are at an increased risk of cancer, reproductive complications and acute toxic events.Design. A structured literature search of Index Medicus/MEDLINE, CINAHL, EMBASE, the Cochrane Database of Systematic Reviews and Healthstar was performed from 1966 to December 2004 for human epidemiological studies evaluating the risk of toxic events in health care workers exposed to cytotoxic drugs. Raw data and adjusted odds ratios (OR) reported in eligible studies were combined using a random effects model to calculate point estimates and 95% confidence intervals (CI) for each potential risk outcome.Main outcome measures. Adjusted OR for congenital malformations, stillbirths and spontaneous abortions among health care workers exposure to cytotoxic agents compared to a non-exposed control group.Results. The systematic review identified 14 studies evaluating the outcomes of interest, seven of which wer...read more
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Journal ArticleDOI
Preventing Occupational Exposures to Antineoplastic Drugs in Health Care Settings
TL;DR: The toxicity of antineoplastic drugs has been well known since they were introduced in the 1940s as mentioned in this paper, and many safety provisions were advanced to reduce worker exposure in the 1980s, but recent studies have shown that workers continue to be exposed to these drugs despite safety policy improvements.
Journal ArticleDOI
Occupational exposures among nurses and risk of spontaneous abortion
Christina C. Lawson,Carissa M. Rocheleau,Elizabeth A. Whelan,Eileen Lividoti Hibert,Barbara Grajewski,Donna Spiegelman,Janet W. Rich-Edwards +6 more
TL;DR: This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion.
Journal ArticleDOI
Reproductive Health Risks Associated with Occupational Exposures to Antineoplastic Drugs in Health Care Settings: A Review of the Evidence
TL;DR: Occupational exposure to antineoplastic drugs seems to raise the risk of both congenital malformations and miscarriage and health care workers with long-term, low-level occupational exposure to these drugs also seem to have an increased risk of adverse reproductive outcomes.
Journal ArticleDOI
Environmental and biological monitoring of antineoplastic drugs in four workplaces in a Swedish hospital
TL;DR: The variability in surface contamination of CP and IF was rather low especially on floors, and the highest surface loads were found on floors that were related to patient activities such as handling of patients’ urine.
Journal ArticleDOI
Guidance Values for Surface Monitoring of Antineoplastic Drugs in German Pharmacies
TL;DR: The introduction of TGVs helps to reduce occupational exposure and allows pharmacy personnel to benchmark their own contamination levels and provides a basis for improvement in occupational safety precautions and for regular contamination controls.
References
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
Posted Content
Risk As Analysis and Risk As Feelings: Some Thoughts About Affect, Reason, Risk, and Rationality
TL;DR: This article addresses the important questions of how to infuse needed "doses of feeling" into circumstances where lack of experience may otherwise leave us too "coldly rational"?
Journal ArticleDOI
Risk as Analysis and Risk as Feelings: Some Thoughts about Affect, Reason, Risk, and Rationality
TL;DR: For instance, this article argued that analytic reasoning cannot be effective unless it is guided by emotion and affect, and argued that rational decision making requires proper integration of both modes of thought.
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Explaining heterogeneity in meta-analysis: a comparison of methods.
TL;DR: In this paper, the authors compared a number of methods which can be used to investigate whether a particular covariate, with a value defined for each study in the meta-analysis, explains any heterogeneity.