Brian Henry

TL;DR: The current study was undertaken to determine the level of light absorption by measuring the molar extinction coefficients (MEC) of a wide range of compounds reported in the literature to have known photosafety issues in humans and the results have shown that all compounds tested have absorbance intensities significantly above an MEC threshold of 1000 L mol (-1)cm(-1) and also display a widerange of photoinstability.

TL;DR: The pH, buffer capacity, surface tension, viscosity and flow rate of both unstimulated (US) and stimulated (SS) human saliva were investigated to provide a platform of reference for future dissolution studies using simulated salivary fluids.

TL;DR: Investigation of this template has revealed that incorporation of a 7-sulfonamide group furnishes a new series of potent and highly selective uPA inhibitors, which were selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers.

TL;DR: Tissues from mdr1a (−/−) mice provide a novel approach for investigating the influence of PGP ablation on intestinal permeability and for resolving PGP and non‐PGP mechanisms that modulate drug permeability.

TL;DR: The probe drugs were successfully delivered in particulate form from the Intelisite capsule in the small intestine and produced expected pharmacokinetic profiles, however drug release in the colon was incomplete and variable possibly due to: low water content, poor mixing, and a high loading dose.