Christopher James Foti

TL;DR: The current study was undertaken to determine the level of light absorption by measuring the molar extinction coefficients (MEC) of a wide range of compounds reported in the literature to have known photosafety issues in humans and the results have shown that all compounds tested have absorbance intensities significantly above an MEC threshold of 1000 L mol (-1)cm(-1) and also display a widerange of photoinstability.

TL;DR: This article summarizes Sessions 1 and 2 of the American Association for Pharmaceutical Scientists (AAPS) Workshop on Predicting and Monitoring Impurities in API and Drug Products and addresses of predicting degradation related impurities and impurity considerations for pharmaceutical dosage forms.

TL;DR: An overview of state-of-the-art technologies being utilized in industry and how they are integrated in a workflow to facilitate structure determination of drug degradation products can be found in this article.

TL;DR: In this article, the present invention discloses novel crystalline and non-crystalline forms of 3-((3R, 4R)-4-methyl-3]-methyl-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-amino]-piperidin -1yl)-3-oxopropionitrile, pharmaceutical composition containing the same, preparations thereof and the uses thereof.

TL;DR: Mass spectrometry and nuclear magnetic resonance were used for structure elucidation, whereas mechanistic studies, including stable isotope labeling experiments, cyanide analysis, and experiments exploring the effects of butylated hydroxyanisole addition, were employed to support the degradation pathways.