Brian K. Alldredge

TL;DR: In this paper, a screen for de novo mutations in patients with two classical epileptic encephalopathies: infantile spasms and Lennox-Gastaut syndrome (n = 115) was performed.

TL;DR: Recommendations were developed based on the literature using standardized assessment methods from the American Heart Association and Grading of Recommendations Assessment, Development, and Evaluation systems, as well as expert opinion when sufficient data were lacking.

TL;DR: Benzodiazepines are safe and effective when administered by paramedics for out-of-hospital status epilepticus in adults and Lorazepam is likely to be a better therapy than diazepam.

TL;DR: Despite the paucity of well-designed randomized controlled trials, practical conclusions and an integrated treatment algorithm for the treatment of convulsive status epilepticus across the age spectrum (infants through adults) can be constructed.

TL;DR: The clinical course of adult patients treated for generalized status epilepticus at the San Francisco General Hospital from 1980 to 1989 is reviewed to determine whether the etiologies of SE have changed over the last two decades, and to investigate the relationships between etiology, response to anticonvulsant therapy, and short-term clinical outcome.