B
Brian Walker
Researcher at Queen's University Belfast
Publications - 246
Citations - 4796
Brian Walker is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Protease & Proteases. The author has an hindex of 35, co-authored 246 publications receiving 4486 citations. Previous affiliations of Brian Walker include Royal College of Surgeons in Ireland & Belfast Health and Social Care Trust.
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Journal ArticleDOI
Proteasome inhibitors in cancer therapy
TL;DR: This review summarises the main mechanisms of action of proteasome inhibitors in cancer, the development of prote asome inhibitors as therapeutic agents and the properties and progress of next generation proteasom inhibitors in the clinic.
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Neutrophil Elastase Activity Is Associated with Exacerbations and Lung Function Decline in Bronchiectasis
James D. Chalmers,Kelly Moffitt,Guillermo Suarez-Cuartin,Oriol Sibila,Simon Finch,Elizabeth Furrie,Alison J. Dicker,Karolina Wrobel,J. Stuart Elborn,Brian Walker,S. Lorraine Martin,Sara E. Marshall,Jeffrey T.-J. Huang,Thomas C. Fardon +13 more
TL;DR: Elevated sputum elastase activity was associated with a higher frequency of exacerbations but was not independently associated with mortality, and candidate biomarkers were tested for their relationship with cross‐sectional markers of disease severity and future risk in adults with bronchiectasis.
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The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells
Susan R. Wilson,Brett Greer,John D. Hooper,Andries Zijlstra,Brian Walker,James P. Quigley,Susan Hawthorne +6 more
TL;DR: How TMPRSS2 may contribute to prostate tumour metastasis via the activation of PAR-2 is described.
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Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.
Lisa J. Crawford,Brian Walker,Huib Ovaa,Dharminder Chauhan,Kenneth C. Anderson,Treen C. M. Morris,Alexandra E. Irvine +6 more
TL;DR: Multiple myeloma cells were more sensitive to induction of apoptosis by PS-341 and MG-132 than BzLLLCOCHO, emphasizing the need for further investigation of the effects of these compounds on gene and protein expression in the cell to allow for the development of more specific and targeted inhibitors.
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Protease-Activated Receptor-2 Involvement in Hypotension in Normal and Endotoxemic Rats In Vivo
Carla Cicala,Aldo Pinto,Mariarosaria Bucci,Raffaella Sorrentino,Brian Walker,Patrick Harriot,A. T. Cruchley,Supriya Kapas,Gareth L. Howells,Giuseppe Cirino +9 more
TL;DR: It is suggested that PAR-2 is important in the regulation of blood pressure in vivo and may represent a new therapeutic target in animals treated with endotoxic shock.