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Alexandra E. Irvine

Researcher at Queen's University Belfast

Publications -  59
Citations -  2177

Alexandra E. Irvine is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Proteasome & Proteasome inhibitor. The author has an hindex of 25, co-authored 59 publications receiving 2022 citations. Previous affiliations of Alexandra E. Irvine include University of Manchester & University of Paris.

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Journal ArticleDOI

Proteasome inhibitors in cancer therapy

Lisa J. Crawford, +2 more
- 31 Jan 2011 - 
TL;DR: This review summarises the main mechanisms of action of proteasome inhibitors in cancer, the development of prote asome inhibitors as therapeutic agents and the properties and progress of next generation proteasom inhibitors in the clinic.
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Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia

P A Courtney, +5 more
- 01 May 1999 - 
TL;DR: Increased circulating apoptotic neutrophils in SLE correlate positively with disease activity (SLAM) and may contribute to autoantigen excess including dsDNA.
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Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132.

Lisa J. Crawford, +6 more
- 15 Jun 2006 - 
TL;DR: Multiple myeloma cells were more sensitive to induction of apoptosis by PS-341 and MG-132 than BzLLLCOCHO, emphasizing the need for further investigation of the effects of these compounds on gene and protein expression in the cell to allow for the development of more specific and targeted inhibitors.
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Guidelines for the measurement of BCR-ABL1 transcripts in chronic myeloid leukaemia

Letizia Foroni, +23 more
- 01 Apr 2011 - 
TL;DR: In this paper, consensus best practice guidelines for real-time quantitative polymerase chain reaction (RT-qPCR) testing, data interpretation and reporting were drawn up and agreed by a consortium of 21 testing laboratories in the United Kingdom and Ireland.
Journal Article

Polyethylene glycol (PEG)-modified granulocyte-macrophage colony-stimulating factor (GM-CSF) with conserved biological activity.

Farooq Malik, +5 more
- 01 Sep 1992 - 
TL;DR: A new coupling method is applied that allows coupling of MPEG directly to proteins under physiological conditions and is, as far as the authors are aware, the first successful construction of PEG-GM-CSF with conserved biological activity.