C
C. M. Harmon
Researcher at University of Michigan
Publications - 12
Citations - 642
C. M. Harmon is an academic researcher from University of Michigan. The author has contributed to research in topics: Enterocyte & Lactobacillus casei. The author has an hindex of 10, co-authored 12 publications receiving 590 citations. Previous affiliations of C. M. Harmon include Boston Children's Hospital.
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Journal ArticleDOI
Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model.
Aladdein Mattar,Daniel H. Teitelbaum,Robert A. Drongowski,F. Yongyi,C. M. Harmon,Arnold G. Coran +5 more
TL;DR: Enteral probiotics such as Lactobacillus casei GG may bind to specific receptor sites on the enterocyte and stimulate the up-regulation of MUC-2, resulting in increased inhibition of BT.
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Effect of probiotics on enterocyte bacterial translocation in vitro
TL;DR: It is demonstrated that the probiotic bacterium LGG inhibits BT of E. coli C25 in a dose-dependent manner in an in-vitro cell-culture model and should be valuable in investigating the cellular and molecular mechanisms involved in the inhibition of pathological enteral bacteria by probiotic agents.
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Evaluation of probiotic treatment in a neonatal animal model.
TL;DR: It is shown that enterally-administered Lacto GG decreases the frequency of E. coli K1A translocation in a neonatal rabbit model, which may have significant implications for the treatment of BT and sepsis in the human neonate.
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Intestinal adaptation in short-bowel syndrome in infants and children: a collective review.
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The effect of phospholipids and fatty acids on tight-junction permeability and bacterial translocation.
TL;DR: The effects of phospholipids other than PC and common FFA on intestinal epithelial permeability and BT appear to have no effect to stimulate BT, which may have clinical implications in the pathogenesis and treatment strategies for IBD patients in whom enterocyte PLA2 activity has been shown to be elevated.