C
Carmen Lema-Martinez
Researcher at Hoffmann-La Roche
Publications - 2
Citations - 1054
Carmen Lema-Martinez is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Chemometrics & Partial least squares regression. The author has an hindex of 2, co-authored 2 publications receiving 972 citations.
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A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
TL;DR: This review focuses on chemometric techniques and pharmaceutical NIRS applications, covering qualitative analyses, quantitative methods and on-line applications for near-infrared spectroscopy for pharmaceutical forms.
Journal ArticleDOI
Near-Infrared Spectroscopy to Determine Residual Moisture in Freeze-Dried Products: Model Generation by Statistical Design of Experiments.
Matthieu Clavaud,Matthieu Clavaud,Carmen Lema-Martinez,Yves Roggo,Michael Bigalke,Aurélie Guillemain,Philippe Hubert,Eric Ziemons,Andrea Allmendinger +8 more
TL;DR: The DoE-based model can be used to monitor MC during drug product development work including scale-up, and transfer without the need to update the NIR model if protein:sugar ratio and MC stays within the tested limits and cake structure remains macroscopically intact.