다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

Variables selection methods in near-infrared spectroscopy.

https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=2232&context=usdaarsfacpub

Qualitative and quantitative analysis of lignocellulosic biomass using infrared techniques: A mini-review

Multivariate data analysis in pharmaceutics: a tutorial review.

Antioxidants: Characterization, natural sources, extraction and analysis

A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.

Terahertz pulsed imaging and near infrared imaging to monitor the coating process of pharmaceutical tablets.

Mechanistic approach in powder blending PAT: Bi-layer mixing and asymptotic end point prediction

The following article gives an overview over the application of near infrared (NIR) spectroscopy during the full-scale manufacturing of oral solid dosage forms in solids manufacturing plants of several pharmaceutical companies in Switzerland and Germany. At-line, on-line and in-line NIR spectroscopy is in use for nearly all process steps such as raw-material identification, blending, drying and tabletting. Most common are at-line applications. For the identification of incoming materials, NIR spectroscopy is already widely applied. The blending of powders or granules is monitored by in-line NIR spectroscopy by several companies, and the water content determination by NIR spectroscopy during drying is also applied in some manufacturing plants. In tablet pressing, at-line and on-line methods for fast in-process controls are more common than 100 % in-line tablet control, which is very challenging due to the speed of the press. Concerning the instrumentation, mainly diode array and acousto-optic tunable filter spectrometers are in use for fast applications such as in-line tabletting, blending or drying monitoring. FT-NIR and grating devices are often used for at-line applications. Fiber optics play an important role in the manufacturing environment.

Lene Maurer

Papers

A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.

Terahertz pulsed imaging and near infrared imaging to monitor the coating process of pharmaceutical tablets.

Mechanistic approach in powder blending PAT: Bi-layer mixing and asymptotic end point prediction

Applications of Near Infrared Spectroscopy in the Full-Scale Manufacturing of Pharmaceutical Solid Dosage Forms