C
Carol Feghali-Bostwick
Researcher at Medical University of South Carolina
Publications - 198
Citations - 11374
Carol Feghali-Bostwick is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Fibrosis & Pulmonary fibrosis. The author has an hindex of 54, co-authored 182 publications receiving 9468 citations. Previous affiliations of Carol Feghali-Bostwick include University of South Carolina & University of Pittsburgh.
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Journal ArticleDOI
Fibroblasts in fibrosis: novel roles and mediators
TL;DR: Many common fibroblast-related features across various physiological and pathological protracted processes are recognized and a new appreciation has emerged for the role of non-cancerous fibro Blast interactions with tumors in cancer progression.
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Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Fei Liu,David Lagares,Kyoung Moo Choi,Lauren E. Stopfer,Aleksandar Marinkovic,Vladimir Vrbanac,Clemens K. Probst,Samantha E. Hiemer,Thomas H. Sisson,Jeffrey C. Horowitz,Ivan O. Rosas,Laura E. Fredenburgh,Carol Feghali-Bostwick,Xaralabos Varelas,Andrew M. Tager,Daniel J. Tschumperlin,Daniel J. Tschumperlin +16 more
TL;DR: Together, these results identify YAP and TAZ as mechanoactivated coordinators of the matrix-driven feedback loop that amplifies and sustains fibrosis.
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Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Zhi Hua Chen,Hong Pyo Kim,Hong Pyo Kim,Frank C. Sciurba,Seon Jin Lee,Seon Jin Lee,Carol Feghali-Bostwick,Donna B. Stolz,Rajiv Dhir,Rodney J. Landreneau,Mathew J. Schuchert,Samuel A. Yousem,Kiichi Nakahira,Kiichi Nakahira,Joseph M. Pilewski,Janet S. Lee,Yingze Zhang,Stefan W. Ryter,Stefan W. Ryter,Augustine M.K. Choi +19 more
TL;DR: A critical role for Egr-1 is demonstrated in promoting autophagy and apoptosis in response to cigarette smoke exposure in vitro and in vivo, suggesting novel therapeutic targets for the treatment of cigarette smoke induced lung injury.
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Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation
Gerald S. Horan,Susan Wood,Victor Ona,Dan Jun Li,Matvey E. Lukashev,Paul H. Weinreb,Kenneth Simon,Kyungmin Hahm,Norm Allaire,Nicola J. Rinaldi,Jaya Goyal,Carol Feghali-Bostwick,Eric L. Matteson,Carl O'Hara,Robert Lafyatis,Gerald S. Davis,Xiaozhu Huang,Dean Sheppard,Shelia M. Violette +18 more
TL;DR: αvβ6 is overexpressed in human lung fibrosis within pneumocytes lining the alveolar ducts and alveol...
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Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.
Xiaomei Wang,Yingze Zhang,Hong Pyo Kim,Zhihong Zhou,Carol Feghali-Bostwick,Fang Liu,Emeka Ifedigbo,Xiaohui Xu,Tim D. Oury,Naftali Kaminski,Augustine M.K. Choi +10 more
TL;DR: Cav-1 was able to suppress TGF-β1–induced ECM production in cultured fibroblasts through the regulation of the c-Jun N-terminal kinase (JNK) pathway and suggests a novel therapeutic target for patients with pulmonary fibrosis.