R
Ryan T. Kendall
Researcher at Medical University of South Carolina
Publications - 9
Citations - 964
Ryan T. Kendall is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Signal transduction & Angiotensin II. The author has an hindex of 7, co-authored 9 publications receiving 721 citations. Previous affiliations of Ryan T. Kendall include University of Tennessee Health Science Center.
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Journal ArticleDOI
Fibroblasts in fibrosis: novel roles and mediators
TL;DR: Many common fibroblast-related features across various physiological and pathological protracted processes are recognized and a new appreciation has emerged for the role of non-cancerous fibro Blast interactions with tumors in cancer progression.
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The β-Arrestin Pathway-selective Type 1A Angiotensin Receptor (AT1A) Agonist [Sar1,Ile4,Ile8]Angiotensin II Regulates a Robust G Protein-independent Signaling Network
Ryan T. Kendall,Erik G. Strungs,Saleh Rachidi,Mi-Hye Lee,Hesham M. El-Shewy,Deirdre K. Luttrell,Michael G. Janech,Michael G. Janech,Louis M. Luttrell +8 more
TL;DR: The findings suggest that AT1A receptors regulate a robust G protein-independent signaling network that affects protein phosphorylation and autocrine/paracrine prostaglandin production and that these pathways can be selectively modulated by biased ligands that antagonize G protein activation.
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Diversity in arrestin function.
TL;DR: The termination of heptahelical receptor signaling is a multilevel process coordinated, in large part, by members of the arrestin family of proteins, and growing evidence suggests that signalsomes regulate such diverse processes as endocytosis and exocythesis, cell migration, survival, and contractility.
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Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis
Ryan T. Kendall,Mi-Hye Lee,Dorea L. Pleasant,Katherine A. Robinson,Dhandapani Kuppuswamy,Dhandapani Kuppuswamy,Paul J. McDermott,Paul J. McDermott,Louis M. Luttrell,Louis M. Luttrell +9 more
TL;DR: The results suggest that in vivo, arrestin pathway-selective AT1 receptor agonists may promote cell growth or hypertrophy through arrestin-mediated mechanisms despite their antagonism of G protein signaling.
Journal ArticleDOI
Angiotensin II activates NF-κB through AT1A receptor recruitment of β-arrestin in cultured rat vascular smooth muscle cells.
Thomas A. Morinelli,Mi-Hye Lee,Ryan T. Kendall,Louis M. Luttrell,Louis M. Luttrell,Linda P. Walker,Michael E. Ullian,Michael E. Ullian +7 more
TL;DR: The purpose of the present study was to examine the interrelationship between AT1AR activation, β-arrestin recruitment, and NF-κB activation in the ability of ANG II to increase COX-2 protein synthesis in RASMC.