C
Christian S. Stohler
Researcher at Columbia University
Publications - 76
Citations - 10118
Christian S. Stohler is an academic researcher from Columbia University. The author has contributed to research in topics: Endogenous opioid & Placebo. The author has an hindex of 40, co-authored 75 publications receiving 9394 citations. Previous affiliations of Christian S. Stohler include Columbia University Medical Center & University of Michigan.
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Journal ArticleDOI
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
Jon Kar Zubieta,Mary M. Heitzeg,Yolanda R. Smith,Joshua A. Bueller,Ke Xu,Yanjun Xu,Robert A. Koeppe,Christian S. Stohler,David Goldman +8 more
TL;DR: Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state.
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The pain-adaptation model: a discussion of the relationship between chronic musculoskeletal pain and motor activity.
TL;DR: It is suggested that the "dysfunction" that is characteristic of several types of chronic musculoskeletal pain is a normal protective adaptation and is not a cause of pain.
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Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Jon Kar Zubieta,Yolanda R. Smith,Joshua A. Bueller,Yanjun Xu,Michael R. Kilbourn,Douglas M. Jewett,Charles R. Meyer,Robert A. Koeppe,Christian S. Stohler +8 more
TL;DR: Sustained pain induced the regional release of endogenous opioids interacting with μ-opioid receptors in a number of cortical and subcortical brain regions, resulting in reductions in the sensory and affective ratings of the pain experience.
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Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Jon Kar Zubieta,Joshua A. Bueller,Lisa R. Jackson,D. Scott,Yanjun Xu,Robert A. Koeppe,Thomas E. Nichols,Christian S. Stohler +7 more
TL;DR: Cognitive factors (e.g., expectation of pain relief) are capable of modulating physical and emotional states through the site-specific activation of μ-opioid receptor signaling in the human brain.
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Neurobiological Mechanisms of the Placebo Effect
TL;DR: It is necessary to eliminate the specific action of a therapy and to simulate a context that is similar in all respects to that of a real treatment to study this psychosocial context.