C
Crystal C. Watkins
Researcher at Johns Hopkins University
Publications - 23
Citations - 1548
Crystal C. Watkins is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Nitric oxide synthase & Acquired immunodeficiency syndrome (AIDS). The author has an hindex of 14, co-authored 23 publications receiving 1428 citations. Previous affiliations of Crystal C. Watkins include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
Andrew A. Pieper,Daniel J. Brat,Daniel J. Brat,David K. Krug,Crystal C. Watkins,Alok Gupta,Seth Blackshaw,Ajay Verma,Zhao-Qi Wang,Solomon H. Snyder +9 more
TL;DR: DNA damage and a major activation of PARP in pancreatic islets of STZ-treated mice are demonstrated and PARP activation may participate in the pathophysiology of type I diabetes, for which PARP inhibitors might afford therapeutic benefit.
Journal ArticleDOI
Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy.
Crystal C. Watkins,Akira Sawa,Samie R. Jaffrey,Seth Blackshaw,Roxanne K. Barrow,Solomon H. Snyder,Christopher D. Ferris,Christopher D. Ferris +7 more
TL;DR: In diabetic animals, delayed gastric emptying can be reversed with a phosphodiesterase inhibitor, sildenafil, and these findings have implications for novel therapeutic approaches and may clarify the etiology of diabetic gastropathy.
Journal ArticleDOI
A Novel Neuron-Enriched Homolog of the Erythrocyte Membrane Cytoskeletal Protein 4.1
Loren D. Walensky,Seth Blackshaw,Dezhi Liao,Crystal C. Watkins,Heinz Ulrich G. Weier,Marilyn Parra,Richard L. Huganir,John G. Conboy,Narla Mohandas,Solomon H. Snyder +9 more
TL;DR: By analogy with the roles of4.1R in red blood cells, 4.1N may function to confer stability and plasticity to the neuronal membrane via interactions with multiple binding partners, including the spectrin-actin–based cytoskeleton, integral membrane channels and receptors, and membrane-associated guanylate kinases.
Journal ArticleDOI
Cognitive impairment in patients with AIDS - prevalence and severity.
TL;DR: The severity and prevalence of the neuropsychiatric complications of HIV including delirium, neurobehavioral impairments (depression), minor cognitive-motor dysfunction, and HIV-associated dementia are reviewed.
Journal ArticleDOI
Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans
Christopher J. Endres,Martin G. Pomper,Michelle L. James,Ovsev Uzuner,Dima A. Hammoud,Crystal C. Watkins,Aaron J. Reynolds,John Hilton,Robert F. Dannals,Michael Kassiou +9 more
TL;DR: This initial study in humans shows that 11C-DPA-713 is a promising ligand for evaluating TSPO binding with PET, and dose-normalized time–activity curves showed that 12C-N,N-diethyl-2-[2-(4-methoxyphenyl)-5,7-dimethyl-pyrazolo]pyrimidin-3-yl]-acetamide gives a larger brain signal.