D
David A. Brenner
Researcher at University of California, San Diego
Publications - 535
Citations - 60517
David A. Brenner is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Hepatic stellate cell & Fibrosis. The author has an hindex of 128, co-authored 499 publications receiving 52756 citations. Previous affiliations of David A. Brenner include Columbia University & United States Department of Veterans Affairs.
Papers
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Journal ArticleDOI
TLR4 enhances TGF-beta signaling and hepatic fibrosis.
Ekihiro Seki,Samuele De Minicis,Samuele De Minicis,Christoph H. Österreicher,Christoph H. Österreicher,Johannes Kluwe,Yosuke Osawa,David A. Brenner,Robert F. Schwabe +8 more
TL;DR: Modulation of TGF-β signaling by a TLR4-MyD88–NF-κB axis provides a novel link between proinflammatory and profibrogenic signals.
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Erratum: Liver fibrosis (Journal of Clinical Investigation (2005) 115 (209-218) DOI:10.1172/JCI200524282)
Ramon Bataller,David A. Brenner +1 more
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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
John J. Lemasters,Anna Liisa Nieminen,Ting Qian,Lawrence C. Trost,Lawrence C. Trost,Steven P. Elmore,Yoshiya Nishimura,Ruth A. Crowe,Wayne E. Cascio,Cynthia A. Bradham,David A. Brenner,Brian Herman +11 more
TL;DR: In vitro findings suggest that the MPT is the pathophysiological mechanism underlying Reye's syndrome in vivo, and a model is proposed in which onset of theMPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death.
Journal Article
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
Christian Jobin,Cynthia A. Bradham,Maria Pia Russo,B Juma,Acharan Narula,David A. Brenner,Ryan Balfour Sartor +6 more
TL;DR: It is concluded that curcumin potently inhibits cytokine-mediated NF-kappa B activation by blocking a signal leading to IKK activity.
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Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney.
TL;DR: These results serve to refocus fibrosis research to injury of the vasculature rather than injury to the epithelium, and suggest that either vascular injury or vascular factors are the most likely triggers for pericyte migration and differentiation into myofibroblasts.