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David A. Lipschitz
Researcher at University of Arkansas for Medical Sciences
Publications - 52
Citations - 4081
David A. Lipschitz is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Bone marrow & Stromal cell. The author has an hindex of 24, co-authored 52 publications receiving 3808 citations. Previous affiliations of David A. Lipschitz include National Center for Toxicological Research & John L. Scott.
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Journal ArticleDOI
Screening for nutritional status in the elderly.
TL;DR: A comprehensive assessment of nutritional status is a critically important component of any patient evaluation and depends on the particular problem discovered and the appropriate intervention plan can be developed.
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Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-γ2 transcription factor and TGF-β/BMP signaling pathways
TL;DR: It is demonstrated that, during aging, the status of mMSC changes with respect to both their intrinsic differentiation potential and production of signaling molecules, which contributes to the formation of a specific marrow microenvironment necessary for maintenance of bone homeostasis.
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Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2.
Beata Lecka-Czernik,Igor Gubrij,Elena J. Moerman,Oumitana Kajkenova,David A. Lipschitz,David A. Lipschitz,Stavros C. Manolagas,Robert L. Jilka +7 more
TL;DR: It is strongly suggested that PPARγ2 negatively regulates stromal cell plasticity by suppressing Osf2/Cbfa1 and osteoblast‐like biosynthetic activity, while promoting terminal differentiation to adipocytes.
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Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia.
Oumitana Kajkenova,Oumitana Kajkenova,Beata Lecka-Czernik,Beata Lecka-Czernik,Igor Gubrij,Igor Gubrij,Simon P. Hauser,Simon P. Hauser,Kenshirou Takahashi,A. Michael Parfitt,Robert L. Jilka,Robert L. Jilka,Stavros C. Manolagas,Stavros C. Manolagas,David A. Lipschitz,David A. Lipschitz +15 more
TL;DR: The evidence that SAMP6 mice exhibit decreased osteoblastogenesis, and increased adipogenesis and myelopoiesis, strongly suggests that a switch in the differentiation program of multipotential mesenchymal progenitors may underlie the abnormal phenotype manifested in the skeleton and other tissues of these animals.
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Effect of age on hematopoiesis in man
TL;DR: The presence of an overall reduction in hematopoiesis in anemic elderly (decreased peripheral blood counts, reduced marrow myeloid precursors, and CFU-C levels) makes it especially likely that a basic cellular abnormality exists.