Oral surgery, oral medicine, oral pathology, oral radiology and endodontics

Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism B Biointerfaces

Nutrition in the Prevention and Treatment of Disease

The world is seeing a quick segment move towards a more established populace, a pattern with significant clinical, social, monetary and political ramifications. Maturing is a multifaceted procedure, including various sub-atomic and cell components with regards to various organ frameworks. A urgent part of maturing is a lot of useful and auxiliary adjustments in the invulnerable framework that can show as a diminished capacity to battle contamination, lessened reaction to inoculation, increased incidence of cancer, higher prevalence of autoimmunity and constitutive lowgrade inflammation, among others. In addition to cell-intrinsic changes in both innate and adaptive immune cells, alteration in the stromal microenvironment in primary and secondary lymphoid organs plays an important role in age-associated immune dysfunction. This review will provide a broad overview of these phenomena and point out some of their clinical and therapeutic implications. This review study setting, discussing the gradual aging immune system. Data for this study is collected from different search engines like PubMed, Google Scholar, MeSH, Semantic scholar, Cochrane, NCBI, Medline, core science. A total of 53 articles were selected. The aging of the immune system is associated with dramatic changes in the distribution and competence of immune cells. Anti-Aging therapy should aim at prolonging T cells’ survival while weakening inflammation prone to innate immunity.

https://cibg.org.au/article_9867_6aed416d016740a2632725618ea66e22.pdf

Aging and Immune System: An Overview

Background and Objectives: The most prevalent and worldwide oral disease is dental caries that affects a significant pro- portion of the world population. There are some classical approaches for control, prevention and treatment of this pathologic condition; however, the results are still not completely successful. Therefore new methods are needed for better management of this important challenge. Chitosan is a natural and non-toxic polysaccharide with many biological applications, particu- larly as an antimicrobial agent. Chitosan nanoparticle is a bioactive and environment friendly material with unique physico- chemical properties. The aim of the present study was to investigate the antimicrobial effect of chitosan and nano-chitosan on the most important cariogenic streptococci. Materials and Methods: For evaluation of antimicrobial effect of chitosan and nano-chitosan against oral streptococci broth micro-dilution method was carried out for four bacterial species; Streptococcus mutans, Streptococcus sobrinus, Streptococ- cus sanguis and Streptococcus salivarius. Also the effect of these materials on adhesion of above bacteria was evaluated. One-way ANOVA and post hoc Tukey test were used for statistical analysis. Results: The MICs of chitosan for S. mutans, S. sanguis, S. salivarius and S. sobrinus were 1.25, 1.25, 0.625 and 0.625 mg/ mL, respectively. The MIC of chitosan nanoparticle for S. mutans, S. salivarius and S. sobrinus was 0.625 mg/mL and for S. sanguis was 0.312 mg/mL. Chitosan and chitosan nanoparticles at a concentration of 5 mg/mL also reduced biofilm forma- tion of S. mutans up to 92.5% and 93.4%, respectively. Conclusion: The results of this study supported the use of chitosan and chitosan nanoparticles as antimicrobial agents against cariogenic Streptococci.

/pdf/evaluation-of-antibacterial-efficiency-of-chitosan-and-3lhmn05m51.pdf

Evaluation of antibacterial efficiency of chitosan and chitosan nanoparticles on cariogenic streptococci: an in vitro study.

The aim of this study was to compare the effectiveness of 2% articaine and 2% lignocaine in achieving adequate anesthesia in children between the age group of 6–13 years using inferior alveolar nerve block. A triple blinded randomized controlled trial was conducted in 180 participants (90 patients- 2% articaine, 90 patients-2% lignocaine). Effectiveness of the anesthetic agent was determined at 3 points determined by subjective evaluation of pain using pain scales (FPS-R). Paired sample t-test and chi square test were performed for statistical significance. Anesthetic success for 2% articaine were 64.4%, 42.2% and 81.8% respectively. The anesthetic success of 2% lignocaine was 66.7%, 48.9% and 85.7% at point one, point two and point three respectively (p > 0.05). This study concludes that 2% articaine in 1:2,00,000 did not demonstrate superior clinical effectiveness in comparison to 2% lignocaine. Lignocaine has always been considered the gold standard. With its unique chemical structure and increased potency, Articaine has been gaining popularity. Its efficacy in 2% concentration had not been compared to 2% lignocaine. 2% articaine did not show clinical superiority but its comparable effectiveness with lignocaine can encourage further research in using articaine in reduced concentrations to improve effectiveness.

Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial.

Introduction Ranula is mucous extravasation cyst that occurs in the floor of the mouth. There are various methods of management of paediatric oral ranula each of which has their own advantage and disadvantage. Aim The aim of this paper was to systematically review the available literature on the management of paediatric oral ranula. Materials and methods A total of 64 articles were retrieved by electronic search. Based on the preset inclusion and exclusion criteria, a total of 21 articles were retrieved for full text analysis. The following characteristics were assessed from the retrieved articles: author, year of publication, study design, sample size, intervention, adverse effects and follow up period. Results The included studies consisted of the following study design: Seven articles were prospective clinical study, four articles were retrospective review, five articles were case series and five articles were case report. The mode of care varied from surgical excision to drug administration and lasers. Conclusion The data obtained from the review, display a lack of high quality study, with proper sample size and adequate follow up period. Further, randomized clinical trials are required to help the clinicians devise a best treatment approach for the management of paediatric oral ranula.

Management of Paediatric Oral Ranula: A Systematic Review.

Objective: The aim of this study was to evaluate the association between lipid peroxidation and dental caries in children with ECC by estimating the levels of MDA in saliva of children. Materials and Methods: A total of 150 children were selected; 75 children with ECC and 75 children without caries (non-ECC). Saliva samples were collected and centrifuged at 12,000 rpm for 24 min at 4°C to obtain a supernatant. MDA levels were estimated by Buege and Aust method by using thiobarbituric acid. The data obtained were analyzed by Student's t -test to compare MDA levels between the groups. Results: MDA levels were higher in children with ECC. There was no statistically significant difference between children with ECC and without ECC (non-ECC). Conclusion: MDA levels were slightly higher in children with ECC, indicating the role of lipid peroxidation in the carious process.

/pdf/comparative-evaluation-of-salivary-malondialdehyde-levels-as-5bpf2lvm6c.pdf

Comparative evaluation of salivary malondialdehyde levels as a marker of lipid peroxidation in early childhood caries.

Dental caries is a disease with multifactorial causes. The prevalence and incidence of dental caries in a population is influenced by a number of risk factor such as sex, age, socioeconomic status, dietary patterns and oral hygiene habits. Thus the present study was designed to assess the prevalence of dental caries in school children in Chidambaram between 5-15 age groups.Materials and methods: The study population consisted of 2362 children, 1258 were boys and 1104 were girls. A total of 7 schools were selected. Trained Dental Surgeon was involved in the examining and the children were examined according to the Dentition status and Treatment Needs, WHO oral health assessment 1987.Results: Off all the three groups, group II (9-11yrs old) should high percentage of caries. In total, dental caries were observed in 1484(63.83%) of study population. The mean (+SD) value of dmft/DMFT of all groups, the decayed teeth accounted for the greatest percentage. In all 80.4%of the student belongs low socio-economic group has showed dental caries . Restoration was the most required treatment in all three groups which was follow by pulp therapy.Conclusion: The result of this study is a pointer to the fact that there still exist a large segment of the population who continue to remain ignorant about the detriment effects of poor oral health and the multiple benefits enjoyed from good oral health.

Prevalence Of Dental Caries, Socio-Economic Status And Treatment Needs Among 5 To 15 Year Old School Going Children Of Chidambaram Prevalence Of Dental Caries, Socio-Economic Status And Treatment Needs Among 5 To 15 Year Old School Going Children Of Chidambaram

Background: Child dental neglect is the failure of a parent or guardian to meet the child's basic oral health needs such that the child enjoys adequate function and freedom from pain and infection, where reasonable resources are available to family or caregiver. Aim: The aim of the study is to evaluate the phenomenon of dental neglect among children in Chennai and to associate dental neglect with oral health status of children aged 3-12 years. Materials and Methods: This is a cross-sectional study involving 478 pairs of parents and children. Dental neglect scale and a questionnaire were used to assess the dental neglect score among parents of the children involved in the study. Oral health status of children was clinically assessed using oral hygiene index, decayed, extracted, filled teeth (def(t)), pulp, ulcers, fistula, abscess (pufa), decayed, missing, filled teeth (DMFT), PUFA as per the World Health Organization criteria and pufa/PUFA index. Student's t-test and one-way ANOVA were used appropriately for statistical analysis using SPSS software version 20.0. Results: A significant higher dental neglect score was reported among the parents who reside in the suburban location (P 3 years (P = 0.001). A significant higher DMFT (P = 0.003), deft (P = 0 < 0.001), pufa (P = 0.011), and debris index (P = 0.002) scores were seen in the higher dental neglect group. Conclusion: Child dental neglect is seen among the parents whose educational qualification was secondary, who reside in the suburban location, and who have not utilized the dental services for more than 3 years in Chennai. This dental neglect results in poorer oral health of children.

Deepa Gurunathan

Papers

Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial.

Management of Paediatric Oral Ranula: A Systematic Review.

Comparative evaluation of salivary malondialdehyde levels as a marker of lipid peroxidation in early childhood caries.

Prevalence Of Dental Caries, Socio-Economic Status And Treatment Needs Among 5 To 15 Year Old School Going Children Of Chidambaram Prevalence Of Dental Caries, Socio-Economic Status And Treatment Needs Among 5 To 15 Year Old School Going Children Of Chidambaram

Dental neglect among children in Chennai.