Detmar Beyersmann

TL;DR: It becomes clear that there exist multiple mechanisms which contribute to the carcinogenicity of cadmium, although the relative weights of these contributions are difficult to estimate.

TL;DR: In general, metal genotoxicity is caused by indirect mechanisms, but specific metal compounds exhibit unique mechanisms such as interruption of cell–cell adhesion by cadmium, direct DNA binding of trivalent chromium, and interaction of vanadate with phosphate binding sites of protein phosphatases.

TL;DR: New hypotheses regarding regulatory functions of zinc ions in cellular signaling pathways are proposed as a conclusion of observations on zinc homeostasis in eukaryotic cells.

TL;DR: In considering the available evidence, the carcinogenic properties of cadmium are interpreted using a multifactorial approach involving indirect genotoxicity (interference with DNA repair) and the upregulation of mitogenic signalling pathways.

TL;DR: Members Mario Altamirano-Lozano, Unidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Facultad de Estudios Superiores-Zaragoza, Battalla del 5 de mayo esq.