Journal ArticleDOI
Functions of zinc in signaling, proliferation and differentiation of mammalian cells.
Detmar Beyersmann,Hajo Haase +1 more
TLDR
New hypotheses regarding regulatory functions of zinc ions in cellular signaling pathways are proposed as a conclusion of observations on zinc homeostasis in eukaryotic cells.Abstract:
Zinc is essential for cell proliferation and differentiation, especially for the regulation of DNA synthesis and mitosis. On the molecular level, it is a structural constituent of a great number of proteins, including enzymes of cellular signaling pathways and transcription factors. Zinc homeostasis in eukaryotic cells is controlled on the levels of uptake, intracellular sequestration in zinc storing vesicles ('zincosomes'), nucleocytoplasmic distribution and elimination. These processes involve the major zinc binding protein metallothionein as a tool for the regulation of the cellular zinc level and the nuclear translocation of zinc in the course of the cell cycle and differentiation. In addition, there is also increasing evidence for a direct signaling function for zinc on all levels of signal transduction. Zinc can modulate cellular signal recognition, second messenger metabolism, protein kinase and protein phosphatase activities, and it may stimulate or inhibit activities of transcription factors, depending on the experimental systems studied. Zinc has been shown to modify specifically the metabolism of cGMP, the activities of protein kinase C and mitogen activated protein kinases, and the activity of transcription factor MTF-1 which controls the transcription of the genes for metallothionein and the zinc transporter ZnT-1. As a conclusion of these observations new hypotheses regarding regulatory functions of zinc ions in cellular signaling pathways are proposed.read more
Citations
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Journal ArticleDOI
Zinc in plants
Martin R. Broadley,Philip J. White,John P. Hammond,Ivan Zelko,Ivan Zelko,Alexander Lux,Alexander Lux +6 more
TL;DR: The dominant fluxes of Zn in the soil-root-shoot continuum are described, including Zn inputs to soils, the plant availability of soluble Zn(2+) at the root surface, and plant uptake and accumulation of ZN.
Journal ArticleDOI
The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.
TL;DR: This review summarizes current progress in the understanding of each ZnT and ZIP transporter from the perspective of zinc physiology and pathogenesis, discussing challenging issues in their structure and zinc transport mechanisms.
Journal ArticleDOI
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
TL;DR: A better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.
Journal ArticleDOI
Zinc is a novel intracellular second messenger
Satoru Yamasaki,Kumiko Sakata-Sogawa,Aiko Hasegawa,Tomoyuki Suzuki,Koki Kabu,Emi Sato,Tomohiro Kurosaki,Susumu Yamashita,Makio Tokunaga,Makio Tokunaga,Keigo Nishida,Toshio Hirano +11 more
TL;DR: The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcɛRI-mediated signaling.
Journal ArticleDOI
Zinc and the immune system
Lothar Rink,P Gabriel +1 more
TL;DR: The relationship between Zn and the immune system is complex, since there are four different types of influence associated with Zn: dietary intake and the resorption of Zn depends on the composition of the diet and also on age and disease status.
References
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Journal ArticleDOI
The biochemical basis of zinc physiology
TL;DR: Majors topics addressed in this review on zinc physiology are chemistry and biochemistry; interface of biochemistry and physiology of zinc; physiology and cell and molecular biology; and pathology.
Journal ArticleDOI
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
Jeremy M Berg,Yigong Shi +1 more
TL;DR: The ability of zinc to be bound specifically within a range of tetrahedral sites appears to be responsible for the evolution of the wide range of zinc-stabilized structural domains now known to exist.
Journal ArticleDOI
Biological chemistry of the elements: J.J.R. Frausto de Silva and R.J.P. Williams Oxford University Press, UK, 1991, pp. 552, ISBN 0 19 855598 9, £60.00
Journal ArticleDOI
The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor
Peter J. Parker,Lisa M. Coussens,Nick Totty,Lucy Rhee,Susan Young,Ellson Y. Chen,Silvia Stabel,Michael D. Waterfield,Axel Ullrich +8 more
TL;DR: The complete amino acid sequence of bovine protein kinase C was determined, revealing a domain structure that shows substantial homology, but not identity, to sequences of other protein kinases.