D
Diederik van de Beek
Researcher at University of Amsterdam
Publications - 13
Citations - 1416
Diederik van de Beek is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Meningitis & Stroke. The author has an hindex of 10, co-authored 13 publications receiving 1115 citations. Previous affiliations of Diederik van de Beek include Leiden University Medical Center & Albert Schweitzer Hospital.
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Journal ArticleDOI
Post-stroke infection: a systematic review and meta-analysis
Willeke F. Westendorp,Paul J. Nederkoorn,Jan-Dirk Vermeij,Marcel G. W. Dijkgraaf,Diederik van de Beek +4 more
TL;DR: The need to prevent infections in patients with stroke is stressed, and pneumonia was associated with death, in a systematic review and meta-analysis of studies on post-stroke infection.
Journal ArticleDOI
The immunology of acute stroke.
Ángel Chamorro,Andreas Meisel,Anna M. Planas,Xabier Urra,Diederik van de Beek,Roland Veltkamp +5 more
TL;DR: The multifaceted role of the immune system in the pathophysiology of acute stroke is discussed, with increased incidence of infections observed after acute stroke, and might result from activation of long-distance feedback loops between the CNS and peripheral immune organs.
Journal ArticleDOI
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
John A. Lees,John A. Lees,Bart Ferwerda,Philip H. C. Kremer,Nicole E. Wheeler,Mercedes Valls Serón,Nicholas J. Croucher,Rebecca A. Gladstone,Hester J. Bootsma,Nynke Y. Rots,Alienke J. Wijmega-Monsuur,Elisabeth A. M. Sanders,Krzysztof Trzciński,Anne L. Wyllie,Anne L. Wyllie,Aeilko H. Zwinderman,Leonard H. van den Berg,Wouter van Rheenen,Jan H. Veldink,Zitta Barrella Harboe,Lene Fogt Lundbo,Lisette C. P. G. M. de Groot,Natasja M. van Schoor,Nathalie van der Velde,Nathalie van der Velde,Lars Ängquist,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Ellen A. Nohr,Alexander J. Mentzer,Tara C. Mills,Julian C. Knight,Mignon du Plessis,Susan A. Nzenze,Jeffrey N. Weiser,Julian Parkhill,Shabir Madhi,Thomas Benfield,Anne von Gottberg,Arie van der Ende,Matthijs C. Brouwer,Jeffrey C. Barrett,Stephen D. Bentley,Diederik van de Beek +43 more
TL;DR: It is found that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility, including pspC and zmpD, which are potential candidates for the development of more broadly-acting pneumococCal vaccines.
Journal ArticleDOI
Antibiotic Therapy for Preventing Infections in People With Acute Stroke
Jan-Dirk Vermeij,Willeke F. Westendorp,Diederik W.J. Dippel,Diederik van de Beek,Paul J. Nederkoorn +4 more
TL;DR: This meta-analysis assessed whether preventive antibiotics in ischemic or hemorrhagic stroke can be improved by preventive antibiotic therapy and how to reduce the risk of a poor functional outcome and the overall infection rate.
Journal ArticleDOI
Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis
John A. Lees,Philip H. C. Kremer,Ana Sousa Manso,Nicholas J. Croucher,Bart Ferwerda,Mercedes Valls Serón,Marco R. Oggioni,Julian Parkhill,Matthijs C. Brouwer,Arie van der Ende,Diederik van de Beek,Stephen D. Bentley +11 more
TL;DR: It is shown that the bacteria capable of causing meningitis are already able to do this upon entering the blood, and no further sequence change is necessary to cross the blood–brain barrier, and this study shows that no genetic adaptation occurs in either invaded niche during bacterialmeningitis for two major pathogen species.