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Dongya Jia
Researcher at Rice University
Publications - 50
Citations - 3600
Dongya Jia is an academic researcher from Rice University. The author has contributed to research in topics: Cancer cell & Epithelial–mesenchymal transition. The author has an hindex of 21, co-authored 42 publications receiving 2711 citations. Previous affiliations of Dongya Jia include University of Science and Technology of China.
Papers
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Journal ArticleDOI
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
Mohit Kumar Jolly,Marcelo Boareto,Marcelo Boareto,Bin Huang,Dongya Jia,Mingyang Lu,Eshel Ben-Jacob,Eshel Ben-Jacob,José N. Onuchic,Herbert Levine +9 more
TL;DR: The operating principles of the core regulatory network for EMT/MET that acts as a “three-way” switch giving rise to three distinct phenotypes – E, M and hybrid E/M are reviewed and a theoretical framework that can elucidate the role of many other players in regulating epithelial plasticity is presented.
Journal ArticleDOI
Tumor Budding: The Name is EMT. Partial EMT.
TL;DR: Based on recent literature, indicating a co-expression of epithelial and mesenchymal markers in many tumor buds, it is posited that tumor budding is a manifestation of this hybrid epithelial/mesenchyal phenotype displaying collective cell migration.
Journal ArticleDOI
Stability of the hybrid epithelial/mesenchymal phenotype
Mohit Kumar Jolly,Satyendra C. Tripathi,Dongya Jia,Steven M. Mooney,Muge Celiktas,Samir M. Hanash,Sendurai A. Mani,Kenneth J. Pienta,Eshel Ben-Jacob,Eshel Ben-Jacob,Herbert Levine +10 more
TL;DR: The results suggest that partial EMT, i.e. a hybrid E/M phenotype, need not be ‘metastable’, and strengthen the emerging notion that partialEMT, but not necessarily a complete E MT, is associated with aggressive tumor progression.
Journal ArticleDOI
HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
De Huang,Tingting Li,Xinghua Li,Long Zhang,Linchong Sun,Xiaoping He,X.C. Zhong,Dongya Jia,Libing Song,Gregg L. Semenza,Ping Gao,Huafeng Zhang +11 more
TL;DR: It is reported that Hif-1α also inhibits fatty acid β-oxidation (FAO), another major source of acetyl-CoA, and a previously unappreciated mechanism by which HIF-1 suppresses FAO to facilitate cancer progression is identified.
Posted Content
Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
Mohit Kumar Jolly,Marcelo Boareto,Bin Huang,Dongya Jia,Mingyang Lu,José N. Onuchic,Herbert Levine,Eshel Ben-Jacob +7 more
TL;DR: In this article, the operating principles of the core regulatory network for EMT/MET are reviewed, which acts as a three-way switch giving rise to three distinct phenotypes - epithelial, mesenchymal and hybrid epithelial/mesenchymals.