E.S. Buescher

TL;DR: The intracellular effect extends conventional electroporation to cellular substructures and opens the potential for new applications in apoptosis induction, gene delivery to the nucleus, or altered cell functions, depending on the electrical pulse conditions.

TL;DR: Experimental studies in which human cells were exposed to pulsed electric fields of up to 300-kV/cm amplitude have confirmed that the application of submicrosecond pulses induces apoptosis (programmed cell death) in biological cells, an effect that has been shown to reduce the growth of tumors.

TL;DR: A new type of field-cell interaction, "Intracellular Electromanipulation", by means of nanosecond pulses at electric fields exceeding 50 kV/cm has been recently added to known bioelectric effects, having the potential to affect transport processes across subcellular membranes, and may be used for gene transfer into cell nuclei.

TL;DR: Experimental studies have confirmed the hypothesis that the application of nanosecond pulses induces a type of programmed cell death, apoptosis, in biological cells, and shown that the similarity law allows one not only to predict cell viability based on pulse parameters, but has also been shown to be applicable for inducing platelet aggregation.

TL;DR: Experimental studies have confirmed that at increased electric fields, the application of nanosecond pulses induces apoptosis (programmed cell death) in biological cells, an effect that has been shown to reduce the growth of tumors.