E
Ed Luther
Researcher at Northeastern University
Publications - 19
Citations - 403
Ed Luther is an academic researcher from Northeastern University. The author has contributed to research in topics: Cancer cell & Doxorubicin. The author has an hindex of 9, co-authored 19 publications receiving 316 citations.
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Journal ArticleDOI
Nanomedicine based curcumin and doxorubicin combination treatment of glioblastoma with scFv-targeted micelles: In vitro evaluation on 2D and 3D tumor models.
Can Sarisozen,Shekhar Dhokai,Edcar G. Tsikudo,Ed Luther,Ilya M. Rachman,Vladimir P. Torchilin,Vladimir P. Torchilin +6 more
TL;DR: The increased efficacy of combination nanoformulations on the spheroids compared to a single agent loaded, or to non-targeted formulations, reinforces the rationale for selection of this combination and successful utilization of GLUT1 scFv as a targeting agent for glioblastoma treatment.
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Mixed Nanosized Polymeric Micelles as Promoter of Doxorubicin and miRNA‐34a Co‐Delivery Triggered by Dual Stimuli in Tumor Tissue
Giuseppina Salzano,Daniel F. Costa,Daniel F. Costa,Can Sarisozen,Ed Luther,George Mattheolabakis,Pooja P. Dhargalkar,Vladimir P. Torchilin,Vladimir P. Torchilin +8 more
TL;DR: The results confirm the potential of the MM to codeliver miRNA-34a and doxorubicin triggered by dual stimuli inherent of tumor tissues.
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Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform
Yilin Zhang,Shravan Kumar Sriraman,Hilary A. Kenny,Ed Luther,Vladimir P. Torchilin,Ernst Lengyel +5 more
TL;DR: It is found that overexpression of P-gp in ovarian cancer is associated with a shorter progression-free and overall survival, and co-delivery of a P- gp inhibitor and paclitaxel using a liposomal platform can sensitize pac litaxel-resistant ovarian cancer cells to paclitAXel.
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Enhanced Cytotoxicity of Folic Acid-Targeted Liposomes Co-Loaded with C6 Ceramide and Doxorubicin: In Vitro Evaluation on HeLa, A2780-ADR, and H69-AR Cells
Shravan Kumar Sriraman,Jiayi Pan,Can Sarisozen,Ed Luther,Vladimir P. Torchilin,Vladimir P. Torchilin +5 more
TL;DR: Overall, this study clearly shows that the co-delivery of C6 ceramide and Dox using a liposomal platform significantly correlates with an antiproliferative effect due to cell cycle regulation and subsequent induction of apoptosis and thus warrants its further evaluation in preclinical animal models.
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Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers.
TL;DR: Novel liposomal formulations surface-modified with a low molecular weight, branched polyethyleneimine (bPEI)–lipid conjugate for use as an alternative to PEG had very good stability characteristics in ion- and protein-rich mediums and tumor growth inhibition was observed in a mouse ovarian xenograft tumor model.