Shravan Kumar Sriraman

TL;DR: This review hopes to provide the reader with a clear understanding and knowledge of biological barriers and the methods to exploit these characteristics to design multifunctional nanocarriers, effect useful dosing regimens and subsequently improve therapeutic outcomes in the clinic.

TL;DR: The PEI-PE/pDNA complexes were mixed with various amounts of micelle-forming material, polyethylene glycol (PEG)-PE to improve biocompatibility and exhibited a neutral surface charge, resistance to salt-induced aggregation, and good transfection activity in the presence of serum in complete media.

TL;DR: Though the dual-targeted liposomes represent an effective cytotoxic formulation in the in vitro setting, they were equally effective in reducing tumor burden in the more complex in vivo setting in this particular model.

TL;DR: It is found that overexpression of P-gp in ovarian cancer is associated with a shorter progression-free and overall survival, and co-delivery of a P- gp inhibitor and paclitaxel using a liposomal platform can sensitize pac litaxel-resistant ovarian cancer cells to paclitAXel.

TL;DR: Overall, this study clearly shows that the co-delivery of C6 ceramide and Dox using a liposomal platform significantly correlates with an antiproliferative effect due to cell cycle regulation and subsequent induction of apoptosis and thus warrants its further evaluation in preclinical animal models.