E
Elena Jones
Researcher at University of Leeds
Publications - 170
Citations - 9753
Elena Jones is an academic researcher from University of Leeds. The author has contributed to research in topics: Mesenchymal stem cell & Bone marrow. The author has an hindex of 44, co-authored 160 publications receiving 8420 citations. Previous affiliations of Elena Jones include Queen Mary University of London & University of Würzburg.
Papers
More filters
Journal ArticleDOI
Bone regeneration: current concepts and future directions
TL;DR: Improved 'local' strategies in terms of tissue engineering and gene therapy, or even 'systemic' enhancement of bone repair, are under intense investigation, in an effort to overcome the limitations of the current methods, to produce bone-graft substitutes with biomechanical properties that are as identical to normal bone as possible.
Journal ArticleDOI
Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies
TL;DR: Data suggest that hMSC numbers obtained by marrow aspiration decline with age and there is an age-related decline in overall BM MSC "fitness" which might lead to problems when using autologous aged MSC for cell-based therapies.
Journal ArticleDOI
Isolation and Characterization of Bone Marrow Multipotential Mesenchymal Progenitor Cells
Elena Jones,Sally E. Kinsey,Anne English,Richard A. Jones,Liz Straszynski,David Meredith,Alex F. Markham,Andrew Jack,Paul Emery,Dennis McGonagle +9 more
TL;DR: This study shows the distinct phenotype, morphology, and method of isolation of BM MPCs, which may have implications for defining the physiologic roles of MPCs in arthritis, bone diseases, and joint regeneration.
Journal ArticleDOI
Mesenchymal multipotency of adult human periosteal cells demonstrated by single‐cell lineage analysis
Cosimo De Bari,Francesco Dell'Accio,Johan Vanlauwe,Jeroen Eyckmans,Ilyas M. Khan,Charles W. Archer,Elena Jones,Dennis McGonagle,Thimios A. Mitsiadis,Costantino Pitzalis,Frank P. Luyten +10 more
TL;DR: It is demonstrated that, regardless of donor age, the adult human periosteum contains cells that, upon enzymatic release and culture expansion, are multipotent MSCs at the single-cell level.
Journal ArticleDOI
Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis
Elena Jones,Anne English,K Henshaw,Sally E. Kinsey,Alex F. Markham,Paul Emery,Dennis McGonagle +6 more
TL;DR: The findings prove the presence of rare tripotential MPCs, at the single-cell level, in the SF of patients with arthritis, and could determine the role of MPCs in the pathogenesis of inflammatory arthritis, together with their role in attempted joint regeneration in degenerative arthritis, which has yet to be established.