E
Erik M. M. Manders
Researcher at University of Amsterdam
Publications - 92
Citations - 8052
Erik M. M. Manders is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Confocal microscopy & Spore. The author has an hindex of 37, co-authored 91 publications receiving 7357 citations. Previous affiliations of Erik M. M. Manders include Ghent University & Royal Institute of Technology.
Papers
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Journal ArticleDOI
Measurement of co-localization of objects in dual-colour confocal images
TL;DR: The co‐localization coefficients can provide relevant quantitative information about the positional relation between biological objects or processes, and are tested on images of real biological specimens.
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Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy.
TL;DR: The results confirm the generally accepted theory that DNA is replicated coordinately in a specific temporal order during the S-phase and conclude that replicon clusters located in the same region are replicated in the the same relatively short period of time.
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Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging
Ron A. Hoebe,C. H. Van Oven,T. W. J. Gadella,P.B. Dhonukshe,P.B. Dhonukshe,C. J. F. Van Noorden,Erik M. M. Manders +6 more
TL;DR: Control light-exposure microscopy (CLEM) is described, a simple imaging approach that reduces photobleaching and phototoxicity two- to tenfold, depending on the fluorophore distribution in the object, and increases the dynamic range of the fluorescence intensity at least twofold.
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Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood
Charlotte A. Oomen,H. Soeters,N. Audureau,Lisa Vermunt,F. N. van Hasselt,Erik M. M. Manders,Marian Joëls,Marian Joëls,Paul J. Lucassen,Harm J. Krugers +9 more
TL;DR: In this article, the authors show that mild early life stress, rather than being overall unfavorable, may program the hippocampus such that it is optimally adapted to a stressful context later in life.
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Numbers and organization of RNA polymerases, nascent transcripts, and transcription units in HeLa nuclei.
TL;DR: The results suggest that many templates are attached in a "cloud" of loops around a site; each site, or transcription "factory," would contain approximately 30 active polymerases and associated transcripts.