J
Jacob A. Aten
Researcher at University of Amsterdam
Publications - 74
Citations - 6118
Jacob A. Aten is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Metaphase & Chromosome. The author has an hindex of 29, co-authored 74 publications receiving 5653 citations. Previous affiliations of Jacob A. Aten include University of Lausanne & Fundamental Research on Matter Institute for Atomic and Molecular Physics.
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Journal ArticleDOI
Measurement of co-localization of objects in dual-colour confocal images
TL;DR: The co‐localization coefficients can provide relevant quantitative information about the positional relation between biological objects or processes, and are tested on images of real biological specimens.
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Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy.
TL;DR: The results confirm the generally accepted theory that DNA is replicated coordinately in a specific temporal order during the S-phase and conclude that replicon clusters located in the same region are replicated in the the same relatively short period of time.
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Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains
Jacob A. Aten,Jan Stap,Przemek M. Krawczyk,Carel H. van Oven,Ron A. Hoebe,Jeroen Essers,Roland Kanaar +6 more
TL;DR: The results support the breakage-first theory to explain the origin of chromosomal translocations and suggest an adhesion process in which the Mre11 complex is implicate.
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Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
Przemek M. Krawczyk,Berina Eppink,Jeroen Essers,Jan Stap,Hans M. Rodermond,Hanny Odijk,Alex N. Zelensky,Chris van Bree,Lukas J.A. Stalpers,Marrije R. Buist,Thomas Soullié,Joost A.P. Rens,Hence J.M. Verhagen,Mark J. O'Connor,Nicolaas A. P. Franken,Timo L.M. ten Hagen,Roland Kanaar,Jacob A. Aten +17 more
TL;DR: It is demonstrated that hyperthermia can be used to sensitize innately HR-proficient tumor cells to PARP-1 inhibitors and that this effect can be enhanced by heat shock protein inhibition.
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Heterochromatin protein 1 is recruited to various types of DNA damage
Martijn S. Luijsterburg,Martijn S. Luijsterburg,Christoffel Dinant,Hannes Lans,Jan Stap,Elzbieta Wiernasz,Elzbieta Wiernasz,Saskia Lagerwerf,Daniël O. Warmerdam,Michael Lindh,Maartje C. Brink,Jurek Dobrucki,Jacob A. Aten,Maria Fousteri,Gert Jansen,Nico P. Dantuma,Wim Vermeulen,Leon H.F. Mullenders,Adriaan B. Houtsmuller,Pernette J. Verschure,Roel van Driel +20 more
TL;DR: This work shows that HP1 proteins are important for DNA repair and may function to reorganize chromatin in response to damage, and analysis of single and double HP1 mutants in nematodes suggests thatHP1 homologues have both unique and overlapping functions in the DDR.