Erin B. Dickerson

TL;DR: The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser.

TL;DR: Findings support the hypothesis that PAX8 plays parallel roles in the development of epithelial ovarian cancer and in the developmental differentiation of coelomic epithelia into endosalpingeal epithelIA.

TL;DR: The synthesis of core/shell hydrogel nanoparticles (nanogels) with surface-localized peptides that specifically target ovarian carcinoma cell lines possessing high expression levels of the Eph2A receptor are described, and a preliminary investigation of gene silencing illustrates that nanogel-mediated delivery of siRNA targeted to the EGF receptor results in knockdown of that receptor.

TL;DR: A modification of the Matrigel plug assay is described which permits a more precise visualization of the angiogenic reaction, provides directional information, requires no histological analysis, and lends itself to photographic documentation and image analysis protocols.

TL;DR: Successful removal of metastatic cancer cells from the abdominal cavity and circulation using magnetic nanoparticle-peptide conjugates indicate the feasibility of a dialysis-like treatment and may improve long-term survival rates of ovarian cancer patients.