F
Fabrice P. Cordelières
Researcher at French Institute of Health and Medical Research
Publications - 36
Citations - 10155
Fabrice P. Cordelières is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: DNA repair & Microscope. The author has an hindex of 19, co-authored 32 publications receiving 8821 citations. Previous affiliations of Fabrice P. Cordelières include Centre national de la recherche scientifique & Curie Institute.
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Journal ArticleDOI
A guided tour into subcellular colocalization analysis in light microscopy
TL;DR: A novel toolbox for subcellular colocalization analysis under ImageJ is created that integrates current global statistic methods and a novel object‐based approach to assess proteins residing on intracellular structures by fluorescence microscopy.
Journal ArticleDOI
BoneJ: Free and extensible bone image analysis in ImageJ.
Michael Doube,Michał M. Kłosowski,Ignacio Arganda-Carreras,Fabrice P. Cordelières,Robert P. Dougherty,Jonathan S. Jackson,Benjamin Schmid,John R. Hutchinson,Sandra J. Shefelbine +8 more
TL;DR: This work implemented standard bone measurements in a novel ImageJ plugin, BoneJ, with which it analysed trabecular bone, whole bones and osteocyte lacunae and found that available software solutions were expensive, inflexible or methodologically opaque.
Journal ArticleDOI
Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules
Laurent Gauthier,Bénédicte C. Charrin,Maria Borrell-Pagès,Jim Dompierre,Hélène Rangone,Fabrice P. Cordelières,Jan De Mey,Marcy E. MacDonald,Volkmar Leßmann,Sandrine Humbert,Frédéric Saudou +10 more
TL;DR: It is shown that huntingtin specifically enhances vesicular transport of brain-derived neurotrophic factor (BDNF) along microtubules, indicating that a key role of huntingtin is to promote BDNF transport and suggesting that loss of this function might contribute to pathogenesis.
Journal ArticleDOI
Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation
Jim Dompierre,Juliette D. Godin,Bénédicte C. Charrin,Fabrice P. Cordelières,Stephen J. King,Sandrine Humbert,Frédéric Saudou +6 more
TL;DR: It is reported here that HDAC inhibitors, including trichostatin A (TSA), increase vesicular transport of brain-derived neurotrophic factor (BDNF) by inhibiting HDAC6, thereby increasing acetylation at lysine 40 of α-tubulin.
Journal ArticleDOI
The IGF-1/Akt Pathway Is Neuroprotective in Huntington's Disease and Involves Huntingtin Phosphorylation by Akt
Sandrine Humbert,Elzbieta A. Bryson,Fabrice P. Cordelières,Nathan C. Connors,Sandeep Robert Datta,Steven Finkbeiner,Michael E. Greenberg,Frédéric Saudou +7 more
TL;DR: It is demonstrated that huntingtin is a substrate of Akt and that phosphorylation of huntingtin by Akt is crucial to mediate the neuroprotective effects of IGF-1 and it is shown that AkT is altered in Huntington's disease patients.