F
Florian Wagner
Researcher at New York University
Publications - 29
Citations - 2808
Florian Wagner is an academic researcher from New York University. The author has contributed to research in topics: Gene & Transcriptome. The author has an hindex of 16, co-authored 27 publications receiving 2131 citations. Previous affiliations of Florian Wagner include Technion – Israel Institute of Technology & Duke University.
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CEL-Seq: Single-Cell RNA-Seq by Multiplexed Linear Amplification
TL;DR: It is shown that CEL-Seq gives more reproducible, linear, and sensitive results than a PCR-based amplification method, and will be useful for transcriptomic analyses of complex tissues containing populations of diverse cell types.
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Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
Reuben Moncada,Dalia Barkley,Florian Wagner,Marta Chiodin,Joseph C. Devlin,Maayan Baron,Cristina H. Hajdu,Diane M. Simeone,Itai Yanai +8 more
TL;DR: Applying multimodal intersection analysis to primary pancreatic tumors, it is found that subpopulations of ductal cells, macrophages, dendritic cells and cancer cells have spatially restricted enrichments, as well as distinct coenrichments with other cell types.
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Developmental milestones punctuate gene expression in the Caenorhabditis embryo
TL;DR: It is demonstrated that embryonic development in five Caenorhabditis species proceeds through two distinct milestones in which the transcriptome is resistant to differences in species-specific developmental timings, suggesting that animal body plans might evolve by uncoupling and elaboration on formerly synchronous processes.
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Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency
Eirini Meimaridou,Julia Kowalczyk,Leo Guasti,Claire Hughes,Florian Wagner,Peter Frommolt,Peter Nürnberg,Mann Np,Banerjee R,Saka Hn,J. P. Chapple,Peter J. King,A.J.L. Clark,Louise A. Metherell +13 more
TL;DR: Using targeted exome sequencing, mutations in NNT, an antioxidant defense gene, in individuals with familial glucocorticoid deficiency are identified and suggest that NNT may have a role in ROS detoxification in human adrenal glands.
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Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
Andre Franke,Jochen Hampe,Philip Rosenstiel,Christian Becker,Florian Wagner,Robert Häsler,Randall D. Little,Klaus Huse,Andreas Ruether,Tobias Balschun,Michael Wittig,Abdou ElSharawy,Gabriele Mayr,Mario Albrecht,Natalie J. Prescott,Clive M. Onnie,Helene Fournier,Tim Keith,Uwe Radelof,Matthias Platzer,Christopher G. Mathew,Monika Stoll,Michael Krawczak,Peter Nürnberg,Stefan Schreiber +24 more
TL;DR: A multi-stage genome-wide scan of 393 German CD cases and 399 controls confirmed an association with the known CD susceptibility gene NOD2, the 5q31 haplotype, and the recently reported CD locus at 5p13.1, and indicated that NELL1 is a ubiquitous IBD susceptibility locus.