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Noa Sher
Researcher at Hebrew University of Jerusalem
Publications - 14
Citations - 2720
Noa Sher is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Gene & Steroidogenic acute regulatory protein. The author has an hindex of 9, co-authored 12 publications receiving 2422 citations. Previous affiliations of Noa Sher include Technion – Israel Institute of Technology & Massachusetts Institute of Technology.
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Journal ArticleDOI
CEL-Seq: Single-Cell RNA-Seq by Multiplexed Linear Amplification
TL;DR: It is shown that CEL-Seq gives more reproducible, linear, and sensitive results than a PCR-based amplification method, and will be useful for transcriptomic analyses of complex tissues containing populations of diverse cell types.
Journal ArticleDOI
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
Sushmita Roy,Jason Ernst,Peter V. Kharchenko,Pouya Kheradpour,Nicolas Nègre,Matthew L. Eaton,Jane M. Landolin,Christopher A. Bristow,Lijia Ma,Michael F. Lin,Stefan Washietl,Bradley I. Arshinoff,Ferhat Ay,Patrick E. Meyer,Nicolas Robine,Nicole L. Washington,Luisa Di Stefano,Eugene Berezikov,Christopher D. Brown,Rogerio Candeias,Joseph W. Carlson,Adrian Carr,Irwin Jungreis,Daniel Marbach,Rachel Sealfon,Michael Y. Tolstorukov,Sebastian Will,Artyom A. Alekseyenko,Carlo G. Artieri,Benjamin W. Booth,Angela N. Brooks,Qi Dai,Carrie A. Davis,Michael O. Duff,X. Feng,Andrey A. Gorchakov,Tingting Gu,Jorja G. Henikoff,Philipp Kapranov,Renhua Li,Heather K. MacAlpine,John H. Malone,Aki Minoda,Jared T. Nordman,Katsutomo Okamura,Marc D. Perry,Sara K. Powell,Nicole C. Riddle,Akiko Sakai,Anastasia Samsonova,Jeremy E. Sandler,Yuri B. Schwartz,Noa Sher,Rebecca Spokony,David Sturgill,Marijke J. van Baren,Kenneth H. Wan,Li Yang,Charles Yu,Elise A. Feingold,Peter J. Good,Mark S. Guyer,Rebecca F. Lowdon,Kami Ahmad,Justen Andrews,Bonnie Berger,Steven E. Brenner,Michael R. Brent,Lucy Cherbas,Sarah C. R. Elgin,Thomas R. Gingeras,Robert L. Grossman,Roger A. Hoskins,Thomas C. Kaufman,W. J. Kent,Mitzi I. Kuroda,Terry L. Orr-Weaver,Norbert Perrimon,Vincenzo Pirrotta,James W. Posakony,Bing Ren,Steven Russell,Peter Cherbas,Brenton R. Graveley,Suzanna E. Lewis,Gos Micklem,Brian Oliver,Peter J. Park,Susan E. Celniker,Steven Henikoff,Gary H. Karpen,Eric C. Lai,David M. MacAlpine,Lincoln Stein,Kevin P. White,Manolis Kellis +95 more
TL;DR: The Drosophila Encyclopedia of DNA Elements (modENCODE) project as mentioned in this paper has been used to map transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines.
Journal ArticleDOI
Developmental control of gene copy number by repression of replication initiation and fork progression
Noa Sher,George W. Bell,Sharon Li,Jared T. Nordman,Thomas Eng,Matthew L. Eaton,David M. MacAlpine,Terry L. Orr-Weaver +7 more
TL;DR: The results establish that developmental control of DNA replication, at both the initiation and elongation stages, is a mechanism to change gene copy number during differentiation.
Journal Article
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
Sushmita Roy,Jason Ernst,Peter V. Kharchenko,Pouya Kheradpour,Nicolas Nègre,Matthew L. Eaton,Jane M. Landolin,Christopher A. Bristow,Lijia Ma,Michael F. Lin,Stefan Washietl,Bradley I. Arshinoff,Ferhat Ay,Patrick E. Meyer,Nicolas Robine,Nicole L. Washington,L. Di Stefano,Eugene Berezikov,Christopher D. Brown,Rogerio Candeias,Joseph W. Carlson,Adrian Carr,Irwin Jungreis,Daniel Marbach,Rachel Sealfon,Michael Y. Tolstorukov,Sebastian Will,Artyom A. Alekseyenko,Carlo G. Artieri,Ben W. Booth,Angela N. Brooks,Qi Dai,Carrie A. Davis,Michael O. Duff,X. Feng,Andrey A. Gorchakov,Tingting Gu,Jorja G. Henikoff,Philipp Kapranov,Renhua Li,Heather K. MacAlpine,John H. Malone,Aki Minoda,Jared T. Nordman,Katsutomo Okamura,Marc D. Perry,Sara K. Powell,Nicole C. Riddle,Akiko Sakai,Anastasia Samsonova,Jeremy E. Sandler,Yuri B. Schwartz,Noa Sher,Rebecca Spokony,David Sturgill,M. van Baren,Kenneth H. Wan,Li Yang,Charles Yu,Elise A. Feingold,Peter J. Good,Mark S. Guyer,Rebecca F. Lowdon,Kami Ahmad,Justen Andrews,Bonnie Berger,Steven E. Brenner,Michael R. Brent,Lucy Cherbas,Sarah C. R. Elgin,Thomas R. Gingeras,Robert L. Grossman,Roger A. Hoskins,Thomas C. Kaufman,W. J. Kent,Mitzi I. Kuroda,Terry L. Orr-Weaver,Norbert Perrimon,Vincenzo Pirrotta,James W. Posakony,Bing Ren,Steven Russell,Peter Cherbas,Brenton R. Graveley,Suzanna E. Lewis,Gos Micklem,Brian Oliver,Peter J. Park,Susan E. Celniker,Steven Henikoff,Gary H. Karpen,Eric C. Lai,David M. MacAlpine,Lincoln Stein,Kevin P. White,Manolis Kellis,D. Acevedo,Richard P. Auburn,Galt P. Barber,Hugo J. Bellen,Eric Bishop,Terri D Bryson,A. Chateigner,J. Chen,Hiram Clawson,C. L. G. Comstock,Sergio Contrino,Leyna DeNapoli,Q. Ding,Alexander Dobin,Marc Domanus,Jorg Drenkow,Sandrine Dudoit,Jacqueline Dumais,Thomas Eng,Delphine Fagegaltier,Sarah Gadel,Somadri Ghosh,F. Guillier,David A. Hanley,Gregory J. Hannon,Kasper D. Hansen,E. Heinz,Angie S. Hinrichs,Martin Hirst,S. Jha,L. Jiang,Y. L. Jung,Helena Kashevsky,Cameron Kennedy,E. Kephart,Laura Langton,O.-K. Lee,S. Li,Zongshan Li,W. Lin,Daniela Linder-Basso,Paul Lloyd,Rachel Lyne,S. E. Marchetti,Marco A. Marra,Nicolas R. Mattiuzzo,Stephanie D. McKay,Folker Meyer,Dianne Miller,Steven W. Miller,Richard A. Moore,Carolyn A. Morrison,Joseph A. Prinz,Michelle Rooks,Richard D. Moore,Kim Rutherford,P. Ruzanov,D. A. Scheftner,Lionel Senderowicz,Parantu K. Shah,Gregory A. Shanower,Raffaella Smith,Eo Stinson,Sarah Suchy,Aaron Tenney,F. Tian,Koen J. T. Venken,Haichao Wang,Robert S. White,Jared Wilkening,Aarron T. Willingham,Chris Zaleski,Z. Zha,D. Zhang,Y. Zhao,Jennifer Zieba +171 more
TL;DR: The modENCODE project as mentioned in this paper has been used to study the functional regulatory network of Drosophila melanogaster and Caenorhabditis elegans worms, including the binding sites of transcription factors.
Journal ArticleDOI
Transcriptional regulation of the cholesterol side chain cleavage cytochrome P450 gene (CYP11A1) revisited: binding of GATA, cyclic adenosine 3',5'-monophosphate response element-binding protein and activating protein (AP)-1 proteins to a distal novel cluster of cis-regulatory elements potentiates AP-2 and steroidogenic factor-1-dependent gene expression in the rodent placenta and ovary.
TL;DR: The findings suggest that upon onset of follicular recruitment, CREB-1 mediates FSH/cAMP signaling, which switches to cAMP-independent expression of P450scc in luteinizing granulosa cells expressing Fra-2, suggesting that placental regulation of P 450scc expression is subjected to alternative signaling pathway(s) yet to be found.