F
Francesca Finotello
Researcher at Innsbruck Medical University
Publications - 68
Citations - 7266
Francesca Finotello is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: Immunotherapy & Medicine. The author has an hindex of 22, co-authored 55 publications receiving 3296 citations. Previous affiliations of Francesca Finotello include University of Padua.
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Journal ArticleDOI
Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
Pornpimol Charoentong,Francesca Finotello,Mihaela Angelova,Clemens Mayer,Mirjana Efremova,Dietmar Rieder,Hubert Hackl,Zlatko Trajanoski +7 more
TL;DR: The immunophenoscore was a superior predictor of response to anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) and anti-programmed cell death protein 1 (anti-PD-1) antibodies in two independent validation cohorts and may help inform cancer immunotherapy and facilitate the development of precision immuno-oncology.
Posted ContentDOI
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
Pornpimol Charoentong,Francesca Finotello,Mihaela Angelova,Clemens Mayer,Mirjana Efremova,Dietmar Rieder,Hubert Hackl,Zlatko Trajanoski +7 more
TL;DR: Cellular characterization of the immune infiltrates revealed a role of cancer-germline antigens in spontaneous immunity and showed that tumor genotypes determine immunophenotypes and tumor escape mechanisms and a scoring scheme for the quantification termed immunophenoscore was developed.
Journal ArticleDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Thomas P. Brouwer,Douglas B. Johnson,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula Ericsson-Gonzalez,Pornpimol Charoentong,Pornpimol Charoentong,Justin M. Balko,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +25 more
TL;DR: QuanTIseq as discussed by the authors is a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data, which is extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data.
Journal ArticleDOI
Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology
Gregor Sturm,Francesca Finotello,Florent Petitprez,Jitao David Zhang,Jan Baumbach,Wolf H. Fridman,Markus List,Tatsiana Aneichyk +7 more
TL;DR: It is demonstrated that computational deconvolution performs at high accuracy for well-defined cell- type signatures and proposed how fuzzy cell-type signatures can be improved, and suggested that future efforts should be dedicated to refining cell population definitions and finding reliable signatures.
Journal ArticleDOI
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
João Fadista,Petter Vikman,Emilia Ottosson Laakso,Inês G. Mollet,Jonathan L.S. Esguerra,Jalal Taneera,Petter Storm,Peter Osmark,Claes Ladenvall,Rashmi B. Prasad,Karin Hansson,Francesca Finotello,K. Uvebrant,Jones K. Ofori,Barbara Di Camillo,Ulrika Krus,Corrado M. Cilio,Ola Hansson,Lena Eliasson,Anders Rosengren,Erik Renström,Claes B. Wollheim,Claes B. Wollheim,Leif Groop +23 more
TL;DR: The data show that the path from genetic variation (SNP) to gene expression is more complex than hitherto often assumed, and that genetic variation can also influence function of a gene by influencing exon usage or splice isoforms (sQTL), allelic imbalance, RNA editing, and expression of noncoding RNAs.