M
Mirjana Efremova
Researcher at Wellcome Trust Sanger Institute
Publications - 43
Citations - 9462
Mirjana Efremova is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Immune system & Cancer immunotherapy. The author has an hindex of 19, co-authored 40 publications receiving 4524 citations. Previous affiliations of Mirjana Efremova include Innsbruck Medical University & Queen Mary University of London.
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Journal ArticleDOI
Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
Pornpimol Charoentong,Francesca Finotello,Mihaela Angelova,Clemens Mayer,Mirjana Efremova,Dietmar Rieder,Hubert Hackl,Zlatko Trajanoski +7 more
TL;DR: The immunophenoscore was a superior predictor of response to anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) and anti-programmed cell death protein 1 (anti-PD-1) antibodies in two independent validation cohorts and may help inform cancer immunotherapy and facilitate the development of precision immuno-oncology.
Journal ArticleDOI
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes.
TL;DR: The structure and content of CellPhoneDB is outlined, procedures for inferring cell–cell communication networks from single-cell RNA sequencing data are provided and a practical step-by-step guide to help implement the protocol is presented.
Journal ArticleDOI
Single-cell reconstruction of the early maternal–fetal interface in humans
Roser Vento-Tormo,Roser Vento-Tormo,Mirjana Efremova,Rachel A. Botting,Margherita Y. Turco,Miquel Vento-Tormo,Kerstin B. Meyer,Jong-Eun Park,Emily Stephenson,Krzysztof Polanski,Angela Goncalves,Angela Goncalves,Lucy Gardner,Staffan Holmqvist,Johan Henriksson,Angela Zou,Andrew M. Sharkey,Ben Millar,Barbara A. Innes,Laura Wood,Anna Wilbrey-Clark,Rebecca Payne,Martin A. Ivarsson,Steve Lisgo,Andrew Filby,David H. Rowitch,Judith N. Bulmer,Gavin J. Wright,Michael J. T. Stubbington,Muzlifah Haniffa,Muzlifah Haniffa,Ashley Moffett,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann +34 more
TL;DR: A single-cell atlas of the maternal–fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success, and develops a repository of ligand–receptor complexes and a statistical tool to predict the cell–cell communication via these molecular interactions.
Journal ArticleDOI
Resolving the fibrotic niche of human liver cirrhosis at single cell level
Prakash Ramachandran,Ross Dobie,John R. Wilson-Kanamori,Elena Dora,Beth E. P. Henderson,N T Luu,N T Luu,Jordan R. Portman,Kylie P. Matchett,M Brice,John A. Marwick,Richard S Taylor,Mirjana Efremova,Roser Vento-Tormo,Neil O. Carragher,Timothy J. Kendall,Jonathan A. Fallowfield,Ewen M Harrison,David R. Mole,David R. Mole,Stephen J. Wigmore,Stephen J. Wigmore,Philip N. Newsome,Philip N. Newsome,Christopher J. Weston,Christopher J. Weston,John P. Iredale,Frank Tacke,Jeffrey W. Pollard,Jeffrey W. Pollard,Chris P. Ponting,John C. Marioni,John C. Marioni,John C. Marioni,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann,Neil C. Henderson +37 more
TL;DR: Analysis of transcriptomes of more than 100,000 single human cells yields molecular definitions for non-parenchymal cell types that are found in healthy and cirrhotic human liver, and identifies markers for scar-associated macrophages and endothelial cells.
Posted ContentDOI
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
Pornpimol Charoentong,Francesca Finotello,Mihaela Angelova,Clemens Mayer,Mirjana Efremova,Dietmar Rieder,Hubert Hackl,Zlatko Trajanoski +7 more
TL;DR: Cellular characterization of the immune infiltrates revealed a role of cancer-germline antigens in spontaneous immunity and showed that tumor genotypes determine immunophenotypes and tumor escape mechanisms and a scoring scheme for the quantification termed immunophenoscore was developed.