F
Frank W. Booth
Researcher at University of Missouri
Publications - 28
Citations - 2364
Frank W. Booth is an academic researcher from University of Missouri. The author has contributed to research in topics: Insulin resistance & Adipose tissue. The author has an hindex of 22, co-authored 28 publications receiving 2104 citations.
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Journal ArticleDOI
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
R. Scott Rector,John P. Thyfault,Grace M. Uptergrove,E. Matthew Morris,Scott P. Naples,Sarah J. Borengasser,Catherine R. Mikus,Matthew J. Laye,M. Harold Laughlin,Frank W. Booth,Jamal A. Ibdah +10 more
TL;DR: It is shown that hepatic mitochondrial dysfunction precedes the development of NAFLD and insulin resistance in the OLETF rats, and evidence suggests that progressive mitochondrial dysfunction contributes to the natural history of obesity-associated NA FLD.
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A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity
Rikke Krogh-Madsen,John P. Thyfault,Christa Broholm,Ole Hartvig Mortensen,Rasmus Huan Olsen,Remi Mounier,Peter Plomgaard,Gerrit van Hall,Frank W. Booth,Bente Klarlund Pedersen +9 more
TL;DR: One possible biological cause for the public health problem of Type 2 diabetes has been identified as reduced ambulatory activity for 2 wk in healthy, nonexercising young men significantly reduced peripheral insulin sensitivity, cardiovascular fitness, and lean leg mass.
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Metabolic responses to reduced daily steps in healthy nonexercising men.
TL;DR: Treatment of cardiovascular risk factors contributes to the high US health care costs, and it is likely that residual morbidity and disability persist even with good treatment, and that medical management is not without cost.
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Lifetime sedentary living accelerates some aspects of secondary aging
TL;DR: Physical inactivity plays a major role in the secondary aging of many essential physiological functions, and this aging can be prevented through a lifetime of physical activity.
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Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction.
TL;DR: This review focuses on the relationship between intracellular ROS formation and ED in endothelial cells or blood vessels exposed to TNF-α to provide insight into the role of this important cytokine in cardiovascular disease.